Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Externalizing disorders: cluster 5 of the proposed meta-structure for DSM-V and ICD-11.
Robert F. Krueger,Susan C. South +1 more
TL;DR: This cluster distinguishes itself by the central role of disinhibitory personality in mental disorders spread throughout sections of the current classifications, including substance dependence, antisocial personality disorder and conduct disorder.
Journal ArticleDOI
Age-Related Changes in the Thickness of Cortical Zones in Humans
TL;DR: A sequential “developmental-sensory” model of aging is proposed, in which developmental factors influence cortical vulnerability relatively early in the aging process, whereas later—in more advanced stages of aging—factors specific to primary sensory and motor cortices confer vulnerability.
Journal ArticleDOI
N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease.
Chun I. Sze,Hong Bi,Bette K. Kleinschmidt-DeMasters,Christopher M. Filley,Christopher M. Filley,Lee J. Martin +5 more
TL;DR: It is demonstrated that NMDA receptor subunits are selectively and differentially reduced in areas of AD brain, and these abnormalities correlate with presynaptic alterations and cognitive deficits in AD.
Journal ArticleDOI
Reactive oxygen species and biological aging: a mechanistic approach.
TL;DR: It will evolve that the in vivo accumulation of oxidized calModulin cannot be the result of the reaction of an individual reactive oxygen species with calmodulin in homogenous solution alone, and complexation of calmodulins to cal modulin-binding proteins and protein turnover are additional parameters likely contributing to the accumulation of specifically modified calmod insulin.
Atlas-based analysis of neurodevelopment from infancy to adulthood using Diffusion Tensor Imaging
Andreia V. Faria,Jia Zhang,Kenichi Oishi,Hangyi Jiang,Kazi Akhter,Koji Sakai,Laurent Hermoye,Michael I. Miller,P.C.M. van Zijl,Susumu Mori,Kennedy Krieger +10 more
TL;DR: Atlas-based tools for time-dependent quantitative image analysis are developed to characterize the anatomical changes that occur from 2years of age to adulthood, and the brainstem anatomy of cerebral palsy patients was evaluated and the altered anatomy was delineated.
References
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