Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal ArticleDOI
The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
TL;DR: Neuropathological aspects of cortical microvessels in aging and AD are reviewed in relationship to known cardiovascular risk factors and their possible impact on the cognitive decline seen in late-onset dementia.
Journal ArticleDOI
BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan.
TL;DR: The peak in both BDNF and trkB TK+ mRNA expression in the neonate temporal cortex differs from that previously described for the frontal cortex where both mRNAs peak in expression during young adulthood, suggesting that neurotrophin signaling is important in the early development of the temporal cortex.
Journal ArticleDOI
Cognitive decline in older adults with a history of traumatic brain injury
Laura Moretti,Irene Cristofori,Starla M. Weaver,Aileen Chau,Jaclyn N. Portelli,Jordan Grafman +5 more
TL;DR: Systematic clinical assessment could help to differentiate between exacerbated cognitive decline and mild cognitive impairment, a precursor of Alzheimer's disease, with important implications for patients and their families.
Journal ArticleDOI
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.
Nobuhisa Iwata,Yoshie Takaki,Shinjiro Fukami,Shinjiro Fukami,Satoshi Tsubuki,Takaomi C. Saido +5 more
TL;DR: Observations suggest that downregulation of neprilysin is likely to be related to AD pathology and to the Aβ deposition associated with normal aging in humans.
Journal ArticleDOI
Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases
TL;DR: Evidence for cell death in the context of individual common neurodegenerative diseases is described and current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43 are discussed.
References
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Journal ArticleDOI
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