Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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The role of calsyntenin-3 in dystrophic neurite formation in Alzheimer's disease brain
Yoko Uchida,Fujiya Gomi +1 more
TL;DR: This review focuses on the mechanism of dystrophic neurite formation by Aß oligomers, and discusses the neurotoxic role of Aβ‐induced calsyntenin‐3 in mediating dyStrophic neurites surrounding Aβ plaques.
Journal ArticleDOI
Entorhinal cortex volume, thickness, surface area and curvature trajectories over the adult lifespan.
TL;DR: This study quantified ERC volume, thickness, surface area, and curvature in a large number of subjects spanning seven decades of life and found that ERC aging began in mid-adulthood, whereas ERC thickness was hemispherically rightward asymmetric, with no gender differences.
A putative role for PCSK9 in synaptic remodelling and plasticity in response to brain injury: implications for Alzheimer's disease
TL;DR: PCSK9 plays an important role incompensatory neuronal repair associated with age, brain injury or chronic degeneration as found in AD, consistent with the relationship that exists between lipid homeostatic processes and AD pathology.
Journal ArticleDOI
[Amyloid-beta peptide metabolism and Alzheimer's disease].
Nobuhisa Iwata,Takaomi C. Saido +1 more
TL;DR: Overexpression of neprilysin decreased both extracellular and intracellular Abeta levels in primary cortical neurons, indicating that up-regulation of nePrilysin activity would be a relevant strategy for therapy and prevention through reduction of the Abeta Levels.
References
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