Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal ArticleDOI
Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
TL;DR: The data suggest that at ages when the fibrillar plaque pathology is present, C1q exerts a detrimental effect on neuronal integrity, most likely through the activation of the classical complement cascade and the enhancement of inflammation.
Journal ArticleDOI
Extended results of the Alzheimer's disease anti-inflammatory prevention trial.
John C.S. Breitner,John C.S. Breitner,Laura D. Baker,Thomas J. Montine,Curtis L. Meinert,Constantine G. Lyketsos,Karen H. Ashe,Karen H. Ashe,Jason Brandt,Suzanne Craft,Denis E. Evans,Robert C. Green,M. Saleem Ismail,Barbara K. Martin,Michael Mullan,Marwan N. Sabbagh,Pierre N. Tariot +16 more
TL;DR: The Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) randomized 2528 elderly persons to naproxen or celecoxib versus placebo for 2 years (standard deviation=11 months) before treatments were terminated as discussed by the authors.
Journal ArticleDOI
The role of apoptosis in the normal aging brain, skeletal muscle, and heart.
TL;DR: The results demonstrate that a tissue‐specific adaptation of the Bcl‐2/Bax ratio occurs with age and may directly influence the release of cytochrome c.
Journal ArticleDOI
Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals
Elizabeth C. Mormino,Rebecca A. Betensky,Trey Hedden,Aaron P. Schultz,Rebecca E. Amariglio,Rebecca E. Amariglio,Dorene M. Rentz,Dorene M. Rentz,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling +10 more
TL;DR: The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals, and both factors are important to consider in upcoming secondary prevention trials targeting CN individuals at high risk for progression to the symptomatic stages of Alzheimer disease.
Journal ArticleDOI
Age and gender effects on microglia and astrocyte numbers in brains of mice.
Peter R. Mouton,Jeffrey M. Long,De-Liang Lei,Victor G. Howard,Mathias Jucker,Michael E. Calhoun,Donald K. Ingram +6 more
TL;DR: It is reported that on average female B6 mice have 25-40% more astrocytes and microglia in DG and CA1 regions than age-matched male C57Bl/6J mice.
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