Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal ArticleDOI
The Association of Aging with White Matter Integrity and Functional Connectivity Hubs.
TL;DR: The results support the compensatory hypothesis of neurocognitive aging theory and reveal the DTI-fMRI relationship associated with normal aging.
Journal ArticleDOI
Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey.
TL;DR: Differences in the properties of dentate granule cells correlated positively with age but not specifically with impairment on the DNMS 2‐minute delay task, suggesting changes in dendritic morphology, input resistance, and inhibitory signaling properties may be part of a constellation of subtle functional changes contributing to age‐associated cognitive impairment.
Book ChapterDOI
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease Introduction
Heiko Braak,Kelly Del Tredici +1 more
TL;DR: The authors may not be able to make you love reading, but neuroanatomy and pathology of sporadic alzheimer s disease will lead you to love reading starting from now.
Book ChapterDOI
Visualizing Pathology Deposits in the Living Brain of Patients with Alzheimer's Disease
TL;DR: 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile, a naphthalene-based radiofluorinated PET imaging probe with binding affinity for amyloid and amyloids-like structures, is developed and applied for in vivo brain imaging of patients with Alzheimer's disease and cognitively normal controls with PET.
Journal ArticleDOI
A review of cell assemblies
TL;DR: This paper reviews literature directly related to the CA, providing a basis of discussion for this interdisciplinary community on this important topic and hopefully will lead to more formal and accurate models of CAs that are better linked to neuropsychological data.
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