Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal ArticleDOI
Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type.
Hiroyuki Umegaki,Hiroyuki Ikari,Hideki Nakahata,Juri Yoshimura,Hidetoshi Endo,Takayuki Yamamoto,Akihisa Iguchi +6 more
TL;DR: Statistical analysis showed that the plasma level of epinephrine during a fasting state in DAT subjects was significantly lower than that of ND subjects; however, in VD subjects the level ofEpinephrine was not different from that ofND subjects, and other values did not differ significantly among the groups.
Journal ArticleDOI
Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause.
Sayuri Higaki,Ken Takumi,Ken Takumi,Mariko Itoh,Gen Watanabe,Gen Watanabe,Kazuyoshi Taya,Kazuyoshi Taya,Keiko Shimizu,Keiko Shimizu,Motoharu Hayashi,Motoharu Hayashi,Motoharu Hayashi,Takao Oishi +13 more
TL;DR: In the brains of ovariectomized and menopausal monkeys, depletion of ovary-derived estrogen brought about different reactions which may be attributed to the senescence of brain aging.
Journal ArticleDOI
Neurocognition of aging in working environments
TL;DR: In this paper, the PFIFF project presented as an example for transfer of neuroscientific basic research to an applied context that aimed at ameliorating and evaluating age-and job-related cognitive deficits.
Journal ArticleDOI
Enriched Environment and White Matter in Aging Brain
TL;DR: This review approached the issue that EE might contribute to normal aging and be beneficial for those suffering from demyelinated diseases by demonstrating that EE recovered spatial memory impairment and increased white matter volume by promoting marked remyelination in aged brain.
Journal ArticleDOI
Postnatal-related changes in the size and total number of neurons in the caudal mesenteric ganglion of dogs: Total number of neurons can be predicted from body weight and ganglion volume
Karina Martinez Gagliardo,Júlio Cesar de Carvalho Balieiro,Romeu Rodrigues de Souza,Antonio Augusto Coppi Maciel Ribeiro +3 more
TL;DR: It was possible to predict the total number of neurons in CMG using both body weight and ganglion volume in an attempt to verify whether or not size and total numberof neurons are both allometrically and aging ruled, i.e., if either the animal's body weight or ganglions volume or aging influence these parameters.
References
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Journal ArticleDOI
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