Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal Article
The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009
TL;DR: A comprehensive review of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present, can be found in this paper, where the strong and weak methodologies for future study design are identified and suggestions for future design will be presented.
Dissertation
Retrospective and prospective memory in healthy and cognitively impaired older adults : using subjective and objective assessment
TL;DR: The aim of this study was to establish a database of historical and present-day memory problems in adults with Alzheimer's disease and to investigate the causes of non-age associated memory decline and its consequences.
Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology
TL;DR: The links between the studies on the Cdk5/p35 system in normal neurogenesis and its claimed participation in neurodegeneration, provide the framework to understand the regulatory relevance of this kinase system, and changes in its regulation that may be implicated in disturbances such as those occurring in Alzheimer disease.
Journal ArticleDOI
[An aging brain: morphofunctional aspects].
TL;DR: Correlations between structural changes in brain tissues and neurochemical and bioelectrical processes in the CNS are discussed and the characteristics of atrophic processes and their severity in different brain structures including cognitive impairment are focused on.
Book ChapterDOI
Nervous System Disorders of Nonhuman Primates and Research Models
TL;DR: Several important nonhuman primate models of human neurologic diseases are highlighted, including models of HIV, Nipah virus, Lyme borelliosis, transmissible spongiform encephlidities, stroke, Parkinson's disease, multiple sclerosis, Huntington's disease.
References
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Journal ArticleDOI
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Journal ArticleDOI
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