Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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A neuronal morphologic type unique to humans and great apes
Esther A. Nimchinsky,Emmanuel Gilissen,John M. Allman,Daniel P. Perl,Joseph M. Erwin,Patrick R. Hof +5 more
TL;DR: The existence and distribution of an unusual type of projection neuron, a large, spindle-shaped cell, in layer Vb of the anterior cingulate cortex of pongids and hominids is reported, which suggests some of the differential neuronal susceptibility that occurs in the human brain in the course of age-related dementing illnesses may have appeared only recently during primate evolution.
Journal ArticleDOI
Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
TL;DR: Findings that implicate hypometabolism and oxidative stress as crucial players in the initiation and progression of synaptic pathology in AD are reviewed.
Journal ArticleDOI
Neuroplasticity Failure in Alzheimer's Disease: Bridging the Gap between Plaques and Tangles
TL;DR: This research examines the role of language impairment in the development of Alzheimer's disease and the role that language impairment plays in the progression of disease.
Journal ArticleDOI
fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease
Reisa A. Sperling,Julianna F. Bates,Elizabeth F. Chua,Andrew Cocchiarella,Dorene M. Rentz,Bruce R. Rosen,Daniel L. Schacter,Marilyn S. Albert +7 more
TL;DR: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
Journal ArticleDOI
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
Caty Casas,Nicolas Sergeant,Jean-Michel Itier,Véronique Blanchard,Oliver Wirths,Nicolien M. van der Kolk,Valérie Vingtdeux,Evita van de Steeg,Gwenaelle Ret,Thierry Canton,Hervé Drobecq,Allan Clark,Bruno Bonici,André Delacourte,Jesus Benavides,Christoph Schmitz,Gunter Tremp,Thomas A. Bayer,Patrick Benoit,Laurent Pradier +19 more
TL;DR: A transgenic mouse model, APP(SL)PS1KI, was presented in this article that closely mimics the development of AD-related neuropathological features including a significant hippocampal neuronal loss.
References
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Journal ArticleDOI
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