Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Book ChapterDOI
Microtubule Dynamics in Neuronal Development, Plasticity, and Neurodegeneration
TL;DR: This review presents a comprehensive overview about the role of microtubules and their dynamic behavior during the formation and maturation of processes and spines in the healthy brain, during aging and under neurodegenerative conditions.
Journal ArticleDOI
A tracking-based diffusion tensor imaging segmentation method for the detection of diffusion-related changes of the cervical spinal cord with aging.
Wim Van Hecke,Alexander Leemans,Jan Sijbers,E. Vandervliet,Johan Van Goethem,Paul M. Parizel +5 more
TL;DR: To compare region of interest (ROI)‐ based and diffusion tensor tractography (DTT)‐based methods for evaluating diffusion properties of the spinal cord as a function of age.
Journal ArticleDOI
Gender differences in predictors of mortality in nursing home residents with AD
Kate L. Lapane,Giovanni Gambassi,Francesco Landi,Antonio Sgadari,Vincent Mor,Roberto Bernabei +5 more
TL;DR: The data suggest that the underlying mechanisms for AD may be different in men and women, with men having an increased risk of mortality relative to women and women having a lower risk of death from the disease itself.
Journal ArticleDOI
Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability.
TL;DR: Genomic differences between sensitive and resistant neurons can now be used to explore the molecular underpinnings of previously suggested mechanisms of cell injury in aging and AD, as well as identify possible molecular and cellular pathways involved in SNV.
Journal ArticleDOI
Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability
Xiaodong Bao,Ranu Pal,Kevin N. Hascup,Yongfu Wang,Wen-Tung Wang,Wenhao Xu,Dongwei Hui,Abdulbaki Agbas,Xinkun Wang,Mary L. Michaelis,In-Young Choi,Andrei B. Belousov,Greg A. Gerhardt,Elias K. Michaelis +13 more
TL;DR: The Tg mice were significantly more resistant than wild-type mice to induction and duration of anesthesia produced by anesthetics that suppress Glu neurotransmission and might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes.
References
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