Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Journal ArticleDOI
Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies
TL;DR: Findings from 56 longitudinal magnetic resonance imaging studies on whole brain volume change in healthy individuals integrate and indicate that whole brainVolume changes throughout the life span.
Journal ArticleDOI
Transgenic mouse models of Alzheimer's disease.
Christopher Janus,David Westaway +1 more
TL;DR: This review discusses transgenic mouse models with well-characterized AD-like neuropathology that show some form of cognitive impairment and argues that conclusions drawn from a limited selection of cross-sectional experiments should be verified in longitudinally designed experiments.
Journal ArticleDOI
The impact of aging and gender on brain viscoelasticity.
Ingolf Sack,Bernd Beierbach,Jens Wuerfel,Dieter Klatt,Uwe Hamhaber,Sebastian Papazoglou,Peter Martus,Jürgen Braun +7 more
TL;DR: The healthy adult brain undergoes steady parenchymal 'liquefaction' characterized by a continuous decline in mu of 0.8% per year (P<0.001), whereas alpha remains unchanged, set the background for using cerebral multifrequency elastography in diagnosing subtle neurodegenerative processes not detectable by other diagnostic methods.
Journal ArticleDOI
Series Introduction: Neurodegeneration: What is it and where are we?
TL;DR: In this Perspective series, selected genetic and molecular advances relevant to the biology of neurodegeneration — e.g., to apoptosis, oxidative stress, and mitochondrial dysfunction — will be reviewed.
Journal ArticleDOI
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis
Jie Zhao,Yifan Fu,Marina V. Yasvoina,Peizhen Shao,Brian Hitt,Tracy O'Connor,Sreemathi Logan,Erika Maus,Martin Citron,Robert W. Berry,Lester I. Binder,Robert Vassar +11 more
TL;DR: It is concluded that BACE1 elevation is most likely triggered by the amyloid pathway and may drive a positive-feedback loop in AD.
References
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Journal ArticleDOI
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