Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
Citations
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Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway.
TL;DR: Treatment with piceatannol is a promising pharmaceutical candidate for the treatment of age-associated diseases and is suggested to ameliorate behavioral disorder and brain injury in an aging mouse model.
Journal ArticleDOI
Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus.
TL;DR: The results suggest that aging is associated with profound sex-dependent and -independent changes in hippocampal sphingolipid profile, and highlights the need to examine the contribution of sphingoipids, and particularly of those containing nervonic acid, in normal and pathological brain aging.
Journal ArticleDOI
Synchronous changes of cortical thickness and corresponding white matter microstructure during brain development accessed by diffusion MRI tractography from parcellated cortex
Tina Jeon,Tina Jeon,Virendra Mishra,Virendra Mishra,Minhui Ouyang,Minhui Ouyang,Min Chen,Hao Huang,Hao Huang +8 more
TL;DR: Revealing the coherence of cortical and WM structural changes during development may open a new window for understanding the underlying mechanisms of developing brain circuits and structural abnormality associated with mental disorders.
Journal ArticleDOI
Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease.
TL;DR: The data strengthens the importance of the ROCK pathway as a therapeutic target in PD, as the increase in protein expression of the growth‐inhibitory protein ROCK2 in astrocytes and a similar trend in microglia, suggests an important role for Rock2 in glial PD pathology.
Journal ArticleDOI
Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals
Rui Li,Shufei Yin,Xinyi Zhu,Weicong Ren,Jing Yu,Pengyun Wang,Zhiwei Zheng,Yanan Niu,Xin Huang,Juan Li +9 more
TL;DR: The results demonstrated a gradual increase in variability in primary regions of the visual, sensorimotor, and auditory networks to specific subcortical structures, particularly the hippocampal formation and the prefrontal and parietal cortices, to the cerebellum.
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