Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
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Concepts of Alzheimer Disease: Biological, Clinical, and Cultural Perspectives
TL;DR: Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.
Journal ArticleDOI
Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma
Grant L. Iverson,Andrew Gardner,Sandy R. Shultz,Gary S. Solomon,Paul McCrory,Ross Zafonte,Ross Zafonte,George Perry,Lili-Naz Hazrati,C. Dirk Keene,Rudolph J. Castellani +10 more
TL;DR: It is argued that CTE pathology cannot be considered inexorably progressive or wholly specific to those who have experienced repetitive neurotrauma, and is instead considered delayed-onset and progressive neurodegenerative disease.
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Age-related reduction in dopamine D1 receptors in the human brain: from late childhood to adulthood, a positron emission tomography study.
TL;DR: The present PET-study provides new evidence on the development of D1DR in humans in vivo which is of critical importance for understanding of the biology of neurodevelopmental disorders.
Journal ArticleDOI
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
Lisa Mosconi,Juha O. Rinne,Wai H. Tsui,Wai H. Tsui,John D. Murray,Yi Li,Lidia Glodzik,Pauline McHugh,Schantel Williams,Megan Cummings,Elizabeth Pirraglia,Stanley J. Goldsmith,Shankar Vallabhajosula,Noora M. Scheinin,Tapio Viljanen,Kjell Någren,Kjell Någren,Mony J. de Leon,Mony J. de Leon +18 more
TL;DR: NL individuals with AD-affected mothers show co-occurring Aβ increases and hypometabolism in AD-vulnerable regions, suggesting an increased risk for AD.
Journal ArticleDOI
Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats.
TL;DR: Interestingly, GAD‐IR boutons did not show a decline in CA1, CA3, or dentate gyrus between middle and old age, and it is possible that loss of CA1 inhibitory interneurons in the dorsal hippocampus contributes to the learning and memory impairments reported in old rats.
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