Journal ArticleDOI
MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
TLDR
In this paper, the role of miR-21 in non-small cell lung cancer (NSCLC) and to clarify the regulation of PTEN by miR21 and determine mechanisms of this regulation were identified.About:
This article is published in Clinica Chimica Acta.The article was published on 2010-06-03. It has received 519 citations till now. The article focuses on the topics: PTEN & Tumor progression.read more
Citations
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PI3K/AKT signaling pathway and cancer: an updated review.
TL;DR: The impact of class I catalytic subunit mutations on AKT-mediated cellular processes that control crucial mechanisms in tumor development are elucidated, exploiting the potential benefits of PI3K signaling inhibitors in clinical use.
Journal ArticleDOI
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
TL;DR: StudyingPTEN in the continuum of rare syndromes, common cancers and mouse models provides insight into the role of PTEN in tumorigenesis and will inform targeted drug development.
Journal ArticleDOI
MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
Mattia Boeri,Carla Verri,Davide Conte,Luca Roz,Piergiorgio Modena,Federica Facchinetti,Elisa Calabrò,Carlo M. Croce,Ugo Pastorino,Gabriella Sozzi +9 more
TL;DR: A role for miRNAs in lung tissues and plasma as molecular predictors of lung cancer development and aggressiveness is indicated and has theoretical and clinical implication for lung cancer management.
Journal ArticleDOI
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
TL;DR: New insights are provided into its anti-oncogenic functions and offer novel opportunities for cancer treatment through restoration of PTEN tumour suppressor activity.
Journal ArticleDOI
PTEN: Multiple Functions in Human Malignant Tumors
Michele Milella,Italia Falcone,Fabiana Conciatori,Ursula Cesta Incani,Anais Del Curatolo,Nicola Inzerilli,Carmen Nuzzo,Vanja Vaccaro,Sabrina Vari,Francesco Cognetti,Ludovica Ciuffreda +10 more
TL;DR: The current understanding of the biological role of PTEN, how PTEN expression and activity are regulated, and the consequences ofPTEN dysregulation in human malignant tumors are discussed.
References
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Journal ArticleDOI
Cancer Statistics, 2009
TL;DR: The most recent data on cancer incidence, mortality, and survival from the American Cancer Society (ACS) is presented in this paper, where the authors compare the three major cancer sites in men (lung, prostate, and colon and rectum [colorectum]) and in two major cancers sites in women (breast and colorectal) over a 15-year period.
Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jing Li,Clifford Yen,Danny Liaw,Katrina Podsypanina,Shikha Bose,Steven I. Wang,Janusz Puc,Christa Miliaresis,Linda Rodgers,Richard W. McCombie,Sandra H. Bigner,Beppino C. Giovanella,Michael Ittmann,B. Tycko,Hanina Hibshoosh,Michael Wigler,Ramon Parsons +16 more
TL;DR: The PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions as discussed by the authors.
Journal ArticleDOI
Real-time quantification of microRNAs by stem–loop RT–PCR
Caifu Chen,Dana Ridzon,Adam Broomer,Zhaohui Zhou,Danny H. Lee,Julie T. Nguyen,Maura Barbisin,Nan Lan Xu,Vikram R. Mahuvakar,Mark R. Andersen,Kaiqin Lao,Kenneth J. Livak,Karl J. Guegler +12 more
TL;DR: A novel microRNA quantification method has been developed using stem–loop RT followed by TaqMan PCR analysis, which enables fast, accurate and sensitive miRNA expression profiling and can identify and monitor potential biomarkers specific to tissues or diseases.
Journal ArticleDOI
Revisions in the International System for Staging Lung Cancer
TL;DR: Analysis of a collected database representing all clinical, surgical-pathologic, and follow-up information for 5,319 patients treated for primary lung cancer confirmed the validity of the TNM and stage grouping classification schema.
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