MicroRNAs: New tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?†
Silvia Giordano,Amedeo Columbano +1 more
TLDR
The possible role of circulating miRNAs as biomarkers, a field that needs urgent improvement in the clinical surveillance of HCC, and the fascinating possibility of using them as therapeutic targets or drugs themselves are discussed.About:
This article is published in Hepatology.The article was published on 2013-02-01 and is currently open access. It has received 328 citations till now.read more
Citations
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Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma
Won Sohn,Jonghwa Kim,So Hee Kang,Se Ra Yang,Ju Yeon Cho,Hyun Chin Cho,Sang Goon Shim,Yong-Han Paik,Yong-Han Paik +8 more
TL;DR: It is suggested that serum exosomal microRNAs may be used as novel serological biomarkers for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B.
Journal ArticleDOI
Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
TL;DR: The common deregulation of small and long nc RNAs in human HCC is summarized and the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis are reviewed and the potential applications of n cRNAs as diagnostic tools and therapeutic targets are discussed.
Journal ArticleDOI
Circulating exosomal noncoding RNAs as prognostic biomarkers in human hepatocellular carcinoma
Yu Rim Lee,Gyeonghwa Kim,Won Young Tak,Se Young Jang,Young Oh Kweon,Jung Gil Park,Hye Won Lee,Young Seok Han,Jae Min Chun,Soo-Young Park,Keun Hur +10 more
TL;DR: This study has provided strong evidence that circulating exosomal ncRNAs (miRNA‐21 and lncRNA‐ATB) are novel prognostic markers and therapeutic targets for HCC.
Journal ArticleDOI
MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST
TL;DR: It is shown that miR-92b was significantly upregulated in tumor tissue and plasma of HCC patients, and its expression level was highly correlated with gender and microvascular invasion, and the importance of XIST/miR- 92b/Smad7 signaling axis in HCC progression is revealed for the first time.
Journal ArticleDOI
MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway
Guohua Lou,Liang Chen,Caixia Xia,Weina Wang,Jinjin Qi,Aichun Li,Liying Zhao,Zhi Chen,Min Zheng,Yanning Liu +9 more
TL;DR: AMSC-Exo- 199a can be an effective vehicle for miR-199a delivery, and they effectively sensitized HCC to chemotherapeutic agents by targeting mTOR pathway and subsequently inhibiting the m TOR pathway.
References
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Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
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Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xi Chen,Yi Ba,Lijia Ma,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jigang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +31 more
TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
Journal ArticleDOI
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
George A. Calin,Manuela Ferracin,Manuela Ferracin,Amelia Cimmino,Gianpiero Di Leva,Masayoshi Shimizu,Sylwia E. Wojcik,Marilena V. Iorio,Rosa Visone,Nurettin Ilfer Sever,Muller Fabbri,Muller Fabbri,Rodolfo Iuliano,Tiziana Palumbo,Flavia Pichiorri,Claudia Roldo,Ramiro Garzon,Cinzia Sevignani,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +24 more
TL;DR: A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.
Journal ArticleDOI
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Robert E. Lanford,Elisabeth S. Hildebrandt-Eriksen,Andreas Petri,Robert Persson,Morten Lindow,Martin E. Munk,Sakari Kauppinen,Sakari Kauppinen,Henrik Ørum +8 more
TL;DR: Treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)–modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no evidence of viral resistance or side effects in the treated animals.
Journal ArticleDOI
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Janaiah Kota,Raghu R. Chivukula,Kathryn A. O'Donnell,Erik A. Wentzel,Chrystal L. Montgomery,Hun-Way Hwang,Tsung Cheng Chang,Perumal Vivekanandan,Michael Torbenson,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Joshua T. Mendell +13 more
TL;DR: It is demonstrated that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is normally expressed at high levels in diverse tissues that may provide a general strategy for miRNA replacement therapies.