Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
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TLDR
In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 1109 citations till now. The article focuses on the topics: Vaccination & Humoral immunity.read more
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A bacteria-based assay to study SARS-CoV-2 protein-protein interactions
TL;DR: In this paper, a bacteria-based two-hybrid (B2H) system was used to analyze the SARS-CoV-2 proteome and identify sixteen distinct intraviral protein-protein interactions (PPIs), involving sixteen proteins.
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Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil
Joilson Xavier,L. Alcantara,Vagner Fonseca,Mauricio Teixeira Lima,Hegger Machado Fritsch,Carla Loane L. Oliveira,Natália Rocha Guimarães,Talita Émile Ribeiro Adelino,Maria Graça Evaristo,Evandra Strazza Rodrigues,E. V. Santos,Debora Glenda Lima de La-Roque,Laise de Moraes,Stephane Tosta,Adelino da Cunha Neto,Alexander Rosewell,Ana F. Mendonça,Anderson Brandao Leite,A.P. Vasconcelos,Bergson de Mendonça Vasconcelos,Camila Amato Montalbano,Camila Zanluca,Carla Micaele De Freitas,Carlos Frederico Campelo de Albuquerque,Claudia Nunes Duarte dos Santos,Cleiton S. Santos,Cliomar Alves dos Santos,Crhistinne Carvalho Maymone Gonçalves,Dalane Loudal Florentino Teixeira,Daniel Ferreira de Lima Neto,Diego G.A. Cabral,Elaine Cristina de Oliveira,Ethel Leonor Noia Maciel,Felicidade Mota Pereira,Felipe Campos de Melo Iani,Gabriela C. G. Andrade,Gabriela Vasconcelos Brito Bezerra,Gislene Garcia de Castro Lichs,Glauco de Carvalho Pereira,Haline Barroso,Iago de Oliveira Gomes,Irina Nastassja Riediger,Isabela Pereira Rodrigues,Isadora Cristina de Siqueira,Jacilane Bezerra da Silva,Jairo Andres Mendez Rico,J. Lima,Jayra Juliana Paiva Alves Abrantes,Jean Phellipe Marques do Nascimento,Judith N. Wasserheit,Julia Borragán Pastor,Jurandy Júnior Ferraz de Magalhães,Kleber Giovanni Luz,Lidio Gonçalves Lima Neto,Livia Carla Vinhal Frutuoso,Ludmila Oliveira Carvalho Sena,Luiz Augusto Pereira,Luiz Henrique Ferraz Demarchi,Marcela Kelly Gómez Astete,Maria Almiron,Maricélia Maia de Lima,Mayra Marinho Presibella,Melissa Barreto Falcão,Michael Gale,Naishe Matos Freire,N. Marques,Noely Fabiana Oliveira de Moura,Pedro Eduardo Almeida da Silva,Peter M. Rabinowitz,Rivaldo Venâncio da Cunha,Karen Soares Trinta,Rodrigo Fabiano do Carmo Said,Rodrigo Bentes Kato,Rodrigo G. Stábeli,Ronaldo de Jesus,Roselene Hans Santos,Simone Kashima Haddad,Svetoslav Nanev Slavov,Tamires de Oliveira Andrade,T. O. A. Rocha,Thiago Lopes Carneiro,Vanessa Brandão Nardy,Vinicius Lourenço da Silva,Wesley C. Van Voorhis,Wildo Navegantes de Araújo,Ana Maria Bispo de Filippis,Marta Giovanetti +86 more
TL;DR: In this paper , the authors used tree branching patterns to characterize the dispersion dynamics of the CHIKV East-Central-South-African (ECSA) lineage in Brazil and found that the northeast region has been the leading hub of virus spread towards other regions.
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Community structure and temporal dynamics of SARS-CoV-2 epistatic network allows for early detection of emerging variants with altered phenotypes
TL;DR: HELEN as mentioned in this paper is a computational framework that identifies densely epistatically connected communities of SAV alleles and merges them into haplotypes using a combination of statistical inference, population genetics, and discrete optimization techniques.
Journal ArticleDOI
SARS-CoV-2 Neutralizing Responses in Various Populations, at the Time of SARS-CoV-2 Variant Virus Emergence: Evaluation of Two Surrogate Neutralization Assays in Front of Whole Virus Neutralization Test
Stéphane Marot,Djeneba Bocar Fofana,Philippe Flandre,Isabelle Malet,Karen Zafilaza,Valentin Leducq,Diane Vivien,Sarah Mrabet,Corentin Poignon,Vincent Calvez,Laurence Morand-Joubert,Anne-Geneviève Marcelin,Joël Gozlan +12 more
TL;DR: In this paper , the authors analyzed the neutralizing response using a virus neutralization test (VNT) against B.1, Alpha, Beta and Omicron variants, and compared the results with two surrogate assays based on antibody-mediated blockage of the ACE2-RBD interaction (Lateral Flow Boditech and ELISA Genscript).
Journal ArticleDOI
Development, Safety, Issues, and Challenges of the SARS-CoV-2 Vaccine
Yasunari Matsuzaka,Ryu Yashiro +1 more
TL;DR: It has been reported that some mutant strains of the new coronavirus escape from neutralizing antibodies acquired by recoverees and vaccine recipients, in which the Omicron strain (B [B] as mentioned in this paper ) is one of the mutants.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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