Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
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In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 1109 citations till now. The article focuses on the topics: Vaccination & Humoral immunity.read more
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Journal ArticleDOI
Current Developments and Challenges of mRNA Vaccines.
TL;DR: The most recent developments of mRNA vaccines against both infectious diseases and cancers are summarized and the challenges are discussed on the basis of these developments.
Posted ContentDOI
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.
Jared Feldman,Julia Bals,Clara G. Altomare,Kerri St. Denis,Evan C. Lam,Blake M. Hauser,Larance Ronsard,Maya Sangesland,Thalia Bracamonte Moreno,Vintus Okonkwo,Nathania Hartojo,Alejandro B. Balazs,Goran Bajic,Daniel Lingwood,Aaron G. Schmidt,Aaron G. Schmidt +15 more
TL;DR: In this article, naive B cells from 8 seronegative human donors targeting the SARS-CoV-2 receptor-binding domain (RBD) were isolated and single B cell analysis showed diverse gene usage with no restricted complementarity determining region lengths.
Journal ArticleDOI
Modeling COVID-19 dynamic using a two-strain model with vaccination
TL;DR: In this paper , a new mathematical model that accounts for two virus variants and the deployment of a vaccination program was proposed to determine the control reproduction number (Rc) and the per day infection, death and recovery rates of each strain in the US pandemic.
Posted ContentDOI
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants
Gerald Wirnsberger,Vanessa Monteil,Brett P Eaton,Elena Postnikova,Michael O. Murphy,Benedict Braunsfeld,Ian Crozier,Franz Kricek,Janine Niederhoefer,Alice Schwarzboeck,Helene Breid,Anna Sanchez Jimenez,Agnes Bugajska-Schretter,Alexander Dohnal,Christine Ruf,Romana Gugenberger,Astrid Hagelkrueys,Nuria Montserrat,Nuria Montserrat,Mike Holbrook,Chris Oostenbrink,Robert H. Shoemaker,Ali Mirazimi,Josef M. Penninger,Josef M. Penninger +24 more
TL;DR: In this article, all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, and Delta, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01).
Journal ArticleDOI
Safety and immunogenicity of an inactivated recombinant Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomised, placebo-controlled, phase 1 trial
Punnee Pitisuttithum,Viravarn Luvira,Saranath Lawpoolsri,Sant Muangnoicharoen,Supitcha Kamolratanakul,Chaisith Sivakorn,P. Narakorn,Somchaiya Surichan,S. Prangpratanporn,Suttida Puksuriwong,Steven Lamola,L D Mercer,Ramappa Raghunandan,Weina Sun,Yonghong Liu,Juan Manuel Carreño,Ram Scharf,Weerapong Phumratanaprapin,Fatima Amanat,Luc Gagnon,Ching-Lin Hsieh,Ruangchai Kaweepornpoj,Sarwat T. Khan,Manjari Lal,Stephen McCroskery,Jason S. McLellan,Ignacio Mena,Marcia Meseck,Benjaluck Phonrat,Yupa Sabmee,R. Singchareon,Stefan Slamanig,Nava Suthepakul,J. Tcheou,Narumon Thantamnu,Sompone Theerasurakarn,Steven P. Tran,Thanakrit Vilasmongkolchai,Jessica A. White,Nina Bhardwaj,Adolfo García-Sastre,Peter Palese,Florian Krammer,Kittisak Poopipatpol,Ponthip Wirachwong,Richard N. Hjorth,Bruce L. Innis +46 more
TL;DR: NDV-HXP-S as mentioned in this paper is an inactivated egg-based recombinant Newcastle disease virus vaccine expressing the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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