Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
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In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 1109 citations till now. The article focuses on the topics: Vaccination & Humoral immunity.read more
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Why US coronavirus tracking can't keep up with concerning variants.
TL;DR: The country has an enormous virus-sequencing capacity, but funding and coordination roadblocks are holding it back as mentioned in this paper, which is a major bottleneck for virus sequencing in the US.
Journal ArticleDOI
New infections by SARS-CoV-2 variants of concern after natural infections and post-vaccination in Rio de Janeiro, Brazil.
Livia R. Goes,Juliana D. Siqueira,Marianne M. Garrido,Brunna M. Alves,Ana Pereira,Claudia Cicala,James Arthos,João P. B. Viola,Marcelo A. Soares +8 more
TL;DR: In this article, the prevalence of different variants of SARS-CoV-2 among recent infections at the Brazilian National Cancer Institute (Rio de Janeiro, Brazil) was assessed by using a Sanger-based sequencing approach targeting the viral S gene to identify VOC.
Journal ArticleDOI
Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States
Lena F. Schimke,Alexandre H.C. Marques,Gabriela Crispim Baiocchi,Caroline Aliane de Souza Prado,Dennyson Leandro M. Fonseca,Paula Paccielli Freire,D. Plaça,Igor S. Filgueiras,Ranieri Coelho Salgado,Gabriel Jansen-Marques,Antonio E R Oliveira,Jean Pierre Schatzmann Peron,Gustavo Cabral-Miranda,José Alexandre Marzagão Barbuto,Niels Olsen Saraiva Câmara,Vera Lúcia Garcia Calich,Hans D. Ochs,Antonio Condino-Neto,Katherine A. Overmyer,Joshua J. Coon,Joseph Balnis,Ariel Jaitovich,Jonas Schulte-Schrepping,Thomas Ulas,Joachim L. Schultze,Helder I. Nakaya,Igor Jurisica,Otavio Cabral-Marques +27 more
TL;DR: This work investigates the transcriptome of 1596 individuals, including patients with COVID-19 in comparison to healthy controls, other acute inflammatory states (HLH), and different respiratory infections (seasonal coronavirus, influenza, bacterial pneumonia), and indicates putative therapeutic pathways for intervention.
Posted ContentDOI
Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity in uninfected and previously infected individuals
Carolina Lucas,Chantal B.F. Vogels,Inci Yildirim,Jessica E. Rothman,Peiwen Lu,Valter Vinicius Silva Monteiro,Gelhausen Jeffrey R,Melissa Campbell,Julio Silva,Alexandra Tabachikova,M. Catherine Munker,Mallery I. Breban,Joseph R. Fauver,Subhasis Mohanty,Jiefang Huang,Yale SARS-CoV Genomic Surveillance Initiative,Albert C. Shaw,Albert I. Ko,Saad B. Omer,Nathan D. Grubaugh,Akiko Iwasaki,Akiko Iwasaki +21 more
TL;DR: In this article, the development of anti-SARS-CoV-2 antibody and T cell responses in previously infected (recovered) or uninfected (naive) individuals that received mRNA vaccines to SARS CoV2 was analyzed.
Journal ArticleDOI
Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics
Aleksandr V Kudriavtsev,Anna V Vakhrusheva,Valery N. Novosеletsky,Marine E. Bozdaganyan,Konstantin V. Shaitan,Mikhail P. Kirpichnikov,Olga Sokolova +6 more
TL;DR: Omicron is a rapidly evolving variant of high concern, whose new subvariants continue to manifest, whose further understanding and the further monitoring of key mutations that provide virus immune escape and/or high affinity towards the receptor could be useful for vaccine and therapeutic development in order to control the evolutionary direction of the COVID-19 pandemic.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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