Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
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In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.About:
This article is published in Cell.The article was published on 2021-04-29 and is currently open access. It has received 1109 citations till now. The article focuses on the topics: Vaccination & Humoral immunity.read more
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Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City
Aldo H. De la Cruz-Montoya,Clara Estela Díaz Velásquez,Héctor Martínez-Gregorio,Miguel Ruiz-de la Cruz,José Bustos-Arriaga,Tannya Castro-Jiménez,Miriam Rodriguez-Sosa,Luis Ignacio Terrazas-Valdés,Luis Jiménez-Alvarez,Nora E. Regino-Zamarripa,Gustavo A. Ramirez-Martínez,Alfredo Cruz-Lagunas,Irlanda Peralta-Arrieta,Leonel Armas-López,B. M. Contreras-Garza,Gabriel Palma-Cortés,Carlos Cabello-Gutiérrez,Renata Báez-Saldaña,Joaquín Zúñiga,Federico Ávila-Moreno,Felipe Vaca-Paniagua +20 more
TL;DR: In this article , through an integrative genomic approach, the authors describe the molecular transition of SARS-CoV-2 by analyzing the viral whole genome sequences from 50 critical COVID-19 patients recruited during the first year of the pandemic in Mexico City.
Journal ArticleDOI
Simultaneous measurement of the antibody responses against SARS-CoV-2 and its multiple variants by a phage display mediated immuno-multiplex quantitative PCR-based assay
Hanyi Chen,Shengbo Eben Li,Jiali Wang,Siqi He,Dong Wang,Zhaohui Qian,Dandan Hu,Fangfang Qi,Keping Hu,C Luo,Jianxun Wang +10 more
TL;DR: A phage display system to distinguish the differences of immune response to antigenic domains of multiple SARS-CoV-2 variants simultaneously by using Phage display mediated immuno-multiplex quantitative PCR (Pi-mqPCR), and data show that this assay is a valuable tool to evaluate the humoral response to the same antigen of different SATS variants or antigens of different pathogens.
Posted ContentDOI
Determinants of early antibody responses to COVID-19 mRNA vaccines in exposed and naive healthcare workers
Gemma Moncunill,Ruth Aguilar,Marta Ribes,Natalia Ortega,Rocío Rubio,Gemma Salmeron,María José Molina,Marta Vidal,Diana Barrios,Robert A. Mitchell,Alfons Jiménez,Cristina Castellana,Pablo Hernández-Luis,Pau Rodo,Susana Méndez,Anna Llupià,Laura Puyol,Natalia Rodrigo Melero,Carlo Carolis,Alfredo Mayor,Luis Izquierdo,Pilar Varela,Antoni Trilla,Anna Vilella,Sonia Barroso,Ana Angulo,Pablo Engel,Marta Tortajada,Alberto L. García-Basteiro,Carlota Dobaño +29 more
TL;DR: In this paper, the authors measured IgA, IgG and IgM levels against SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from the wild-type and S from the Alpha, Beta and Gamma variants of concern, after BNT162b2 (Pfizer/BioNTech) or mRNA-1273 vaccination in a cohort of health care workers (N=578).
Journal ArticleDOI
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron
Li-mei Hao,Tien-Ying Hsiang,Ronit R. Dalmat,Reneé C. Ireton,Jennifer F Morton,Caleb Stokes,Jason Netland,Malika Hale,Christopher D. Thouvenel,Anna Wald,Nicholas Franko,Kristen Huden,Helen Y. Chu,Alex Sigal,Alexander L. Greninger,S. Tilles,Lynn K. Barrett,Wesley C. Van Voorhis,Jennifer E. Munt,Trevor Scobey,Ralph S. Baric,David J. Rawlings,Marion Pepper,Paul K. Drain,Michael Gale +24 more
TL;DR: A clinic-to-lab virus isolation and characterization pipeline was established to rapidly isolate, sequence, and characterize SARS-CoV-2 variants, and a virus neutralization assay was applied to quantitate humoral immunity from infection and/or vaccination as discussed by the authors .
Journal ArticleDOI
The emergence of new SARS-CoV-2 omicron subvariants introduces uncertainty about the end of the COVID-19 pandemic
TL;DR: The emergence of new SARS-CoV-2 omicron subvariants introduces uncertainty about the end of the COVID-19 pandemic as discussed by the authors , which is the most recent subvirus outbreak.
References
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Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Nina Le Bert,Anthony T. Tan,Kamini Kunasegaran,Christine Y.L. Tham,Morteza Hafezi,Adeline Chia,Melissa Hui Yen Chng,Meiyin Lin,Meiyin Lin,Nicole Tan,Martin Linster,Wan Ni Chia,Mark I-Cheng Chen,Lin-Fa Wang,Eng Eong Ooi,Shirin Kalimuddin,Paul A. Tambyah,Jenny G. Low,Jenny G. Low,Yee-Joo Tan,Yee-Joo Tan,Antonio Bertoletti,Antonio Bertoletti +22 more
TL;DR: Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.
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