Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Evaluation of visual recognition memory in MCI patients.
Emmanuel J. Barbeau,Mira Didic,Eve Tramoni,Olivier Felician,Sven Joubert,A. Sontheimer,Mathieu Ceccaldi,Michel Poncet +7 more
TL;DR: The DMS48, a test of visual recognition memory, is impaired early in the course of patients with amnestic mild cognitive impairment, suggesting a profile of genuine memory impairment related to medial temporal lobe lesions.
Journal ArticleDOI
Repetition priming in normal aging and Alzheimer's disease: a review of findings and theories.
TL;DR: A comprehensive review of the literature on repetition priming in normal aging and Alzheimer's disease is provided to articulate the issues that are critical to interpreting the empirical results, and discuss what new conclusions are suggested by the overall pattern of findings.
Journal ArticleDOI
TDP-43 is intercellularly transmitted across axon terminals
Marisa S. Feiler,Benjamin Strobel,Axel Freischmidt,Anika M. Helferich,Julia Kappel,Bryson M. Brewer,Deyu Li,Dietmar Rudolf Thal,Paul Walther,Albert C. Ludolph,Karin M Danzer,Jochen H. Weishaupt +11 more
TL;DR: A protein complementation assay quantifying TDP-43 oligomerization in living neurons shows microvesicular and bidirectional synaptic transmission of TDP -43 and T DP-43 seeding activity in human ALS postmortem brain tissue.
Journal ArticleDOI
Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery
Panos Theofilas,Alexander J. Ehrenberg,Sara Dunlop,Ana Tereza Di Lorenzo Alho,Austin Nguy,Renata Elaine Paraizo Leite,Roberta Diehl Rodriguez,Maria B. Mejia,Claudia K. Suemoto,Renata Eloah de Lucena Ferretti-Rebustini,Livia Polichiso,Camila F. Nascimento,William W. Seeley,Ricardo Nitrini,Carlos Augusto Pasqualucci,Wilson Jacob Filho,Udo Rueb,John Neuhaus,Helmut Heinsen,Helmut Heinsen,Lea T. Grinberg,Lea T. Grinberg +21 more
TL;DR: The brainstem's locus coeruleus is the first area to develop neurofibrillary changes (NFTs) in AD, emphasizing the need to characterize those brain areas that degenerate first.
Journal ArticleDOI
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.
Michelle C. Janelsins,Michael A. Mastrangelo,Salvatore Oddo,Frank M. LaFerla,Howard J. Federoff,William J. Bowers +5 more
TL;DR: The data provide evidence for early induction of inflammatory processes in a model that develops amyloid and neurofibrillary tangle pathology and link inflammatory processes within the entorhinal cortex, which represents one of the earliest AD-affected brain regions.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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