Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Amyloid Beta Induces Oxidative Stress-Mediated Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy
Anna Carrano,Jeroen J.M. Hoozemans,Saskia M. van der Vies,Annemieke J.M. Rozemuller,Jack van Horssen,Helga E. de Vries +5 more
TL;DR: The data evidently show that Aβ is toxic to brain endothelial cells via binding to RAGE and induction of ROS production, which ultimately leads to disruption of TJs and loss of BBB integrity.
Journal ArticleDOI
Argyrophilic Grain Disease Is a Sporadic 4-Repeat Tauopathy
Takashi Togo,Naruhiko Sahara,Shu Hui Yen,Natalie Cookson,Takashi Ishizawa,Mike Hutton,Rohan de Silva,Andrew J. Lees,Dennis W. Dickson +8 more
TL;DR: The results suggest that AGD, PSP and CBD are 4R tauopathies that share common pathologic, biochemical, and genetic characteristics.
Journal ArticleDOI
MRI of entorhinal cortex in mild Alzheimer's disease.
Matthew Bobinski,Mony J. de Leon,Antonio Convit,Susan De Santi,Jerzy Wegiel,Chaim Tarshish,L. A. Saint Louis,Henryk M. Wisniewski +7 more
Journal ArticleDOI
Olfactory Identification and Incidence of Mild Cognitive Impairment in Older Age
Robert S. Wilson,Julie A. Schneider,Steven E. Arnold,Yuxiao Tang,Patricia A. Boyle,David A. Bennett +5 more
TL;DR: Impaired odor identification was associated with a lower level of global cognition at baseline and with more rapid decline in episodic memory, semantic memory, and perceptual speed.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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