Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.
Clifford R. Jack,Val J. Lowe,Stephen D. Weigand,Heather J. Wiste,Matthew L. Senjem,David S. Knopman,Maria M. Shiung,Jeffrey L. Gunter,Bradley F. Boeve,Bradley J. Kemp,Michael Weiner,Ronald C. Petersen +11 more
TL;DR: The data from this study are consistent with a model of typical late onset Alzheimer's disease that has two main features: (i) dissociation between the rate of amyloid deposition and the rates of neurodegeneration late in life, with amyloids deposition proceeding at a constant slow rate while neurodegenersation accelerates and (ii) clinical symptoms are coupled to neurodegneration not amyloidal deposition.
Journal ArticleDOI
Modulation of neurodegeneration by molecular chaperones.
TL;DR: It is proposed that molecular chaperones are neuroprotective because of their ability to modulate the earliest aberrant protein interactions that trigger pathogenic cascades.
Journal ArticleDOI
Axonal Pathology in Traumatic Brain Injury
TL;DR: The current understanding of DAI as a uniquely mechanical injury, its histopathological identification, and its acute and chronic pathogenesis following TBI are reviewed.
Journal ArticleDOI
Primary age-related tauopathy (PART): a common pathology associated with human aging
John F. Crary,John Q. Trojanowski,Julie A. Schneider,Jose F. Abisambra,Erin L. Abner,Irina Alafuzoff,Steven E. Arnold,Johannes Attems,Thomas G. Beach,Eileen H. Bigio,Nigel J. Cairns,Dennis W. Dickson,Marla Gearing,Lea T. Grinberg,Lea T. Grinberg,Patrick R. Hof,Bradley T. Hyman,Kurt A. Jellinger,Gregory A. Jicha,Gabor G. Kovacs,David S. Knopman,Julia Kofler,Walter A. Kukull,Ian R. A. Mackenzie,Eliezer Masliah,Ann C. McKee,Thomas J. Montine,Melissa E. Murray,Janna H. Neltner,Ismael Santa-Maria,William W. Seeley,Alberto Serrano-Pozo,Michael L. Shelanski,Thor D. Stein,Masaki Takao,Dietmar Rudolf Thal,Jonathan B. Toledo,Juan C. Troncoso,Jean Paul G. Vonsattel,Charles L. White,Thomas Wisniewski,Randall L. Woltjer,Masahito Yamada,Peter T. Nelson +43 more
TL;DR: A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.
Journal ArticleDOI
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Nigel J. Cairns,Eileen H. Bigio,Ian R. A. Mackenzie,Manuela Neumann,Virginia M.-Y. Lee,Kimmo J. Hatanpaa,Charles L. White,Julie A. Schneider,Lea T. Grinberg,Glenda M. Halliday,Charles Duyckaerts,James Lowe,Ida Elisabeth Holm,Markus Tolnay,Koichi Okamoto,Hideaki Yokoo,Shigeo Murayama,John Woulfe,David G. Munoz,Dennis W. Dickson,Paul G. Ince,John Q. Trojanowski,David M. A. Mann +22 more
TL;DR: The aim of this study was to improve the neuropathologic recognition and provide criteria for the pathological diagnosis in the neurodegenerative diseases grouped as frontotemporal lobar degeneration (FTLD) and incorporate up-to-date neuropathology in the light of recent immunohistochemical, biochemical, and genetic advances.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more