Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
TL;DR: There is a long prodromal phase between the formation of protein aggregates and the appearance of the first clinical symptoms, which manifest only after extensive propagation, opening novel therapeutic avenues.
Journal ArticleDOI
Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia.
Sebastiaan Engelborghs,Karen De Vreese,Tom Van de Casteele,Hugo Vanderstichele,Bart Van Everbroeck,Patrick Cras,Jean-Jacques Martin,Eugeen Vanmechelen,Peter Paul De Deyn +8 more
TL;DR: The value of biomarkers in differential dementia diagnosis was shown, using pathological diagnosis as a reference, with new models achieving sensitivity, specificity and diagnostic accuracy levels, consistently exceeding 80%.
Journal ArticleDOI
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Jacob W. Vogel,Alexandra L. Young,Neil P. Oxtoby,Ruben Smith,Rik Ossenkoppele,Rik Ossenkoppele,Olof Strandberg,Renaud La Joie,Leon M Aksman,Michel J. Grothe,Michel J. Grothe,Yasser Iturria-Medina,Alzheimer's Disease Neuroimaging Initiative,Michael J. Pontecorvo,Michael D. Devous,Gil D. Rabinovici,Daniel C. Alexander,Chul Hyoung Lyoo,Alan C. Evans,Oskar Hansson +19 more
TL;DR: Using tau-positron emission tomography scans from 1,612 individuals, this paper identified four distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%.
Journal ArticleDOI
Glutamatergic systems in Alzheimer's disease
TL;DR: Histological studies and biochemical evidence suggest loss of pyramidal neurones and their synapses in Alzheimer's disease (AD), this together with biochemical evidence suggests presynaptic (and postsynaptic) glutamatergic hypoactivity, which represents a ‘double blow’ as the activity of glutamatorgic neurones is heavily influenced by the cholinergic system, which is also dysfunctional in AD.
Journal ArticleDOI
Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
Jonathan H. Morra,Zhuowen Tu,Liana G. Apostolova,Amity E. Green,Christina Avedissian,Sarah K. Madsen,Neelroop N. Parikshak,Arthur W. Toga,Clifford R. Jack,Norbert Schuff,Michael W. Weiner,Paul M. Thompson +11 more
TL;DR: 3D hippocampal volume loss rates increased with worsening diagnosis, and correlated with both baseline and interval changes in Mini-Mental State Examination (MMSE) scores and global and sum-of-boxes Clinical Dementia Rating scale (CDR) scores.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more