Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
More filters
Journal ArticleDOI
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
Thomas G. Beach,Charles H. Adler,Lucia I. Sue,Linda Vedders,Lih-Fen Lue,Charles L. White,Haru Akiyama,John N. Caviness,Holly A. Shill,Marwan N. Sabbagh,Douglas G. Walker +10 more
TL;DR: Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread, and within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density.
Journal ArticleDOI
Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients With Alzheimer Disease
Kooresh Shoghi-Jadid,Gary W. Small,Eric D. Agdeppa,Vladimir Kepe,Linda M. Ercoli,Prabha Siddarth,Stephen L. Read,Nagichettiar Satyamurthy,Andrej Petrič,Sung-Cheng Huang,Jorge R. Barrio +10 more
TL;DR: This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments.
Journal ArticleDOI
Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.
Melissa E. Murray,Neill R. Graff-Radford,Owen A. Ross,Ronald C. Petersen,Ranjan Duara,Dennis W. Dickson +5 more
TL;DR: H hippocampal sparing and limbic-predominant AD subtypes might account for about 25% of cases, and hence should be considered when designing clinical, genetic, biomarker, and treatment studies in patients with AD, and support the hypothesis that AD has distinct clinicopathological subtypes.
Journal ArticleDOI
Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations
Anne M. Cataldo,Corrinne M. Peterhoff,Juan C. Troncoso,Teresa Gomez-Isla,Bradley T. Hyman,Ralph A. Nixon +5 more
TL;DR: Early endosomal abnormalities provide a mechanistic link between EP alterations, genetic susceptibility factors, and Abeta generation and suggest differences that may be involved in Abetageneration and beta amyloidogenesis in subtypes of AD.
Journal ArticleDOI
The neuropathology of probable Alzheimer disease and mild cognitive impairment.
TL;DR: The objective of this study was to investigate single and mixed common age‐related neuropathologies in persons with probable AD and MCI.
References
More filters
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more