Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
Mariet Allen,Minerva M. Carrasquillo,Cory C. Funk,Benjamin D. Heavner,Fanggeng Zou,Curtis S. Younkin,Jeremy D. Burgess,High Seng Chai,Julia E. Crook,James A. Eddy,Hong-Dong Li,Ben Logsdon,Mette A. Peters,Kristen K. Dang,Xue Wang,Daniel J. Serie,Chen Wang,Thuy Nguyen,Sarah Lincoln,Kimberly G. Malphrus,Gina Bisceglio,Ma Li,Todd E. Golde,Lara M. Mangravite,Yan W. Asmann,Nathan D. Price,Ronald C. Petersen,Neill R. Graff-Radford,Dennis W. Dickson,Steven G. Younkin,Nilufer Ertekin-Taner +30 more
TL;DR: This work has analyzed gene expression levels in the brain tissue of subjects with AD and related diseases and expects that these datasets will enable investigators to explore and identify transcriptional mechanisms contributing to neurodegenerative diseases.
Journal ArticleDOI
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases.
TL;DR: A systematic and comprehensive summary of the existing knowledge of lncRNAs is given in order to provide a better understanding of this new studying field and highlight recent studies related lnc RNAs in central nervous system development and neurodegenerative diseases.
Journal ArticleDOI
Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
TL;DR: Blood flow alterations with subsequent hypoperfusion induced by CAA-related capillary occlusion presumably point to a second mechanism in which Aβ adversely affects the brain in AD in addition to its direct neurotoxic effects.
Journal ArticleDOI
Neural correlates of Alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients
TL;DR: A systematic and quantitative meta-analysis reveals that early Alzheimer's disease affects structurally the (trans-)entorhinal and hippocampal regions, functionally the inferior parietal lobules and precuneus and contributes to standardized imaging inclusion criteria for Alzheimer's Disease as suggested for future diagnostic systems.
Journal ArticleDOI
β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
TL;DR: Interestingly, it was found that most pathologic measures correlated highly with the severity of dementia, however, the strongest predictor of premortem cognitive dysfunction on all three cognitive measures was the relative area of entorhinal cortex occupied by beta-amyloid deposition.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more