Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT.
Daiji Kogure,Hiroshi Matsuda,Takashi Ohnishi,Takashi Asada,Masatake Uno,Toshiyuki Kunihiro,Seigo Nakano,Masaru Takasaki +7 more
TL;DR: SPM analysis showed the characteristic early-AD rCBF pattern of selective decrease and longitudinal decline, which may be overlooked by a conventional region-of-interest technique with observer a priori choice and hypothesis, may closely relate to the pathophysiologic process of this disease.
Journal ArticleDOI
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.
Tara L. Spires,Jennifer D. Orne,Karen S. SantaCruz,Rose Pitstick,George A. Carlson,Karen H. Ashe,Bradley T. Hyman +6 more
TL;DR: Results imply that neurofibrillary tangles do not necessarily lead to neuronal death, because there was loss of neurons before neurofibillary lesions appeared in the dentate gyrus and, conversely, neuro fibrillary pathology appeared without major cell loss in the striatum.
Alzheimer disease models and human neuropathology: similarities and diVerences
TL;DR: In this article, a triply trans- genic model (mutated APP, PS1 and tau) was used to investigate the mechanisms of neuro-nal loss, the accumulation of A in the cell body of the neu- rons, inXammation and gliosis.
Journal ArticleDOI
Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis.
Heiko Braak,E. Braak +1 more
TL;DR: It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
Journal ArticleDOI
Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
Irina Alafuzoff,Thomas Arzberger,Safa Al-Sarraj,Istvan Bodi,Nenad Bogdanovic,Heiko Braak,Orso Bugiani,Kelly Del-Tredici,Isidro Ferrer,Ellen Gelpi,Giorgio Giaccone,Manuel B. Graeber,Paul G. Ince,Wouter Kamphorst,Andrew T. King,Penelope Korkolopoulou,Gabor G. Kovacs,Sergey Larionov,David Meyronet,Camelia M. Monoranu,Piero Parchi,Efstratios Patsouris,Wolfgang Roggendorf,Danielle Seilhean,Fabrizio Tagliavini,Christine Stadelmann,Nathalie Streichenberger,Dietmar Rudolf Thal,Dietmar Rudolf Thal,Stephen B. Wharton,Hans A. Kretzschmar +30 more
TL;DR: The results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures, whereas when only mild subtle lesions were present the agreement was poorer, and it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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