Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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The neuropathology of genetic Parkinson's disease.
TL;DR: In gathering together all studies of PD autopsies with an identified genetic risk, this review highlights the wealth of information generated as well as shortcomings in the available data, and there is a need for larger, unbiased pathological studies.
Journal ArticleDOI
CXCR3-Dependent Microglial Recruitment Is Essential for Dendrite Loss after Brain Lesion
Angelika Rappert,Ingo Bechmann,Tatyana Pivneva,Jacqueline Mahlo,Knut Biber,Christiane Nolte,Adam D. Kovac,Craig Gerard,Hendrikus Boddeke,Robert Nitsch,Helmut Kettenmann +10 more
TL;DR: It is shown that CXCR3 signaling is crucial in microglia recruitment but not proliferation, and this recruitment is an essential element for neuronal reorganization.
Journal ArticleDOI
Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.
Nobuyuki Okamura,Shozo Furumoto,Michelle T. Fodero-Tavoletti,Rachel S. Mulligan,Ryuichi Harada,Paul Yates,Svetlana Pejoska,Yukitsuka Kudo,Colin L. Masters,Kazuhiko Yanai,Christopher C. Rowe,Victor L. Villemagne +11 more
TL;DR: Interestingly, unlike 11C-Pittsburgh compound B, 18F-THK5105 retention was significantly correlated with cognitive parameters, hippocampal and whole brain grey matter volumes, which was consistent with findings from previous post-mortem studies showing significant correlations of neurofibrillary tangle density with dementia severity or neuronal loss.
Journal ArticleDOI
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.
Kristina R. Patterson,Christine L. Remmers,Yifan Fu,Sarah M. Brooker,Nicholas M. Kanaan,Laurel Vana,Sarah Ward,Juan F. Reyes,Keith D. Philibert,Marc J. Glucksman,Lester I. Binder +10 more
TL;DR: In this paper, a photochemical cross-linking technique was employed to examine intermolecular interactions of full-length Tau in vitro and showed that dimerization is an early event in the Tau aggregation process and that these dimers self-associate to form larger oligomeric aggregates.
Journal ArticleDOI
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.
Eric Karran,John Hardy +1 more
TL;DR: In the past 5 years, there have been 6 amyloidocentric programs that completed phase 3 clinical testing and none met their primary outcome measures, although 1, solanezumab, showed encouraging results in a prespecified secondary outcome measure.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more