Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
More filters
Journal ArticleDOI
Hippocampal formation glucose metabolism and volume losses in MCI and AD.
Susan De Santi,Mony J. de Leon,Mony J. de Leon,Henry Rusinek,Antonio Convit,Antonio Convit,Chaim Tarshish,Alexandra Roche,Wai Hon Tsui,Emad Kandil,Madhu Boppana,Katherine Daisley,Gene-Jack Wang,David J. Schlyer,Joanna S. Fowler +14 more
TL;DR: Cross-sectional data show that in MCI hippocampal formation changes exist without significant neocortical changes, which best characterize AD, while in both MCI and AD, metabolism reductions exceed volume losses.
Journal ArticleDOI
Alzheimer's Disease: From Pathology to Therapeutic Approaches
TL;DR: An overview of the field is given and the "amyloid hypothesis" of Alzheimer's disease is given particular attention, since the majority of the ongoing therapeutic approaches are based on its theoretical framework.
Journal ArticleDOI
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.
TL;DR: Therapeutic strategies that improve elimination of Abeta and other soluble metabolites from the brain may prevent cognitive decline in Alzheimer's disease.
Journal ArticleDOI
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
Ronald J. Killiany,Bradley T. Hyman,Teresa Gomez-Isla,Mark B. Moss,Ron Kikinis,Ferenc A. Jolesz,Rudolph E. Tanzi,Kenneth J. Jones,Marilyn S. Albert +8 more
TL;DR: Findings are consistent with neuropathologic data showing substantial involvement of the entorhinal cortex in the preclinical phase of AD and suggest that, as the disease spreads, atrophic change develops within the hippocampus, which is measurable on MRI.
Journal ArticleDOI
Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia
Clare J. Galton,Karalyn Patterson,Kim S. Graham,M. A. Lambon-Ralph,Guy B. Williams,Nagui M. Antoun,Barbara J. Sahakian,John R. Hodges +7 more
TL;DR: Hippocampal atrophy is not specific for AD but is also seen in semantic dementia, and these findings have implications for diagnosis and understanding of the cognitive deficits in AD and semantic dementia.
References
More filters
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more