Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Volume reduction of the entorhinal cortex in subjective memory impairment.
Frank Jessen,Ludger Feyen,Katrin Freymann,Ralf Tepest,Wolfgang Maier,Reinhard Heun,H. H. Schild,Lukas Scheef +7 more
TL;DR: The results mirror the temporal sequence of neurodegeneration in AD and support the concept of SMI as the first clinical manifestation of dementia.
Journal ArticleDOI
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment
Lior Weissman,Dong-Gyu Jo,Martin M. Sørensen,Nadja C. de Souza-Pinto,William R. Markesbery,Mark P. Mattson,Vilhelm A. Bohr +6 more
TL;DR: The results support the hypothesis that defective BER may play an important role in the progression of AD and suggest that BER dysfunction is a general feature of AD brains which could occur at the earliest stages of the disease.
Journal ArticleDOI
TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia.
Bryan D. James,Robert S. Wilson,Patricia A. Boyle,John Q. Trojanowski,David A. Bennett,Julie A. Schneider +5 more
TL;DR: It is observed that TDP-43 proteinopathy was very common, frequently mixed with pathological Alzheimer's disease, and associated with a higher likelihood of the clinical expression of clinical Alzheimer's-type dementia but only when extended beyond the amygdala.
Journal ArticleDOI
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain
Winnie S. Liang,Travis Dunckley,Thomas G. Beach,Andrew Grover,Diego Mastroeni,Douglas G. Walker,Richard J. Caselli,Walter A. Kukull,Daniel W. McKeel,John C. Morris,Christine M. Hulette,Donald E. Schmechel,Gene E. Alexander,Eric M. Reiman,Joseph Rogers,Dietrich A. Stephan +15 more
TL;DR: In this article, gene expression profiles from laser capture micro-dissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains were compared.
Journal ArticleDOI
Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis
TL;DR: The aim is not only to re‐evaluate the original key claims of the hypothesis with a critical eye but also to identify gaps in knowledge required to validate relevant claims and delineate additional studies and/or data that are needed.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more