Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.
Vijay R. Varma,Anup M. Oommen,Sudhir Varma,Ramon Casanova,Yang An,Ryan M. Andrews,Richard O'Brien,Olga Pletnikova,Juan C. Troncoso,Jon B. Toledo,Rebecca Baillie,Matthias Arnold,Gabi Kastenmueller,Kwangsik Nho,P. Murali Doraiswamy,Andrew J. Saykin,Rima Kaddurah-Daouk,Cristina Legido-Quigley,Madhav Thambisetty +18 more
TL;DR: Different sphingolipid species identified map to several biologically relevant pathways implicated in AD, including tau phosphorylation, amyloid-β (Aβ) metabolism, calcium homeostasis, acetylcholine biosynthesis, and apoptosis.
Journal ArticleDOI
Longitudinal tau PET in ageing and Alzheimer's disease.
Clifford R. Jack,Heather J. Wiste,Christopher G. Schwarz,Val J. Lowe,Matthew L. Senjem,Prashanthi Vemuri,Stephen D. Weigand,Terry M. Therneau,Dave S Knopman,Jeffrey L. Gunter,David T.W. Jones,Jonathan Graff-Radford,Kejal Kantarci,Rosebud O. Roberts,Michelle M. Mielke,Mary M. Machulda,Ronald C. Petersen +16 more
TL;DR: It is reported that in clinically symptomatic stages of Alzheimer’s disease, tau accumulation occurs throughout the brain, rather than only in specific areas.
Journal ArticleDOI
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
A. R. Merdes,L. A. Hansen,Dilip V. Jeste,Douglas Galasko,C. R. Hofstetter,Gilbert Ho,Leon J. Thal,Jody Corey-Bloom +7 more
TL;DR: In a recent comparative clinicopathologic study of 98 autopsy-proven cases of dementia with Lewy bodies (DLB), Merdes et al. as discussed by the authors found that DLB patients with low Braak stages (0-2) had a higher frequency of visual hallucinations and extrapyramidal signs (EPS) but a nonsignificantly higher degree of EPS than those with high NEs (3-6), suggesting that the degree of concomitant AD tangle pathology has an important influence on both clinical features and clinical diagnostic accuracy of DLB.
Journal ArticleDOI
Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
TL;DR: Evidence that the kynurenine pathway is up‐regulated in Alzheimer's disease (AD) brain, leading to increases in the excitotoxin quinolinic acid (QUIN) is provided, implying that QUIN may be involved in the complex and multifactorial cascade leading to neuro‐degeneration in AD.
Journal ArticleDOI
Cognitive Decline and Brain Volume Loss as Signatures of Cerebral Amyloid-β Peptide Deposition Identified With Pittsburgh Compound B: Cognitive Decline Associated With Aβ Deposition
TL;DR: The in vivo measure of cerebral amyloidosis known as [(11)C]PiB is associated with cross-sectional regionally specific brain atrophy and longitudinal cognitive decline in multiple cognitive domains that occur before the clinical diagnosis of Alzheimer disease.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more