Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.
Rachel E. Bennett,Ashley B. Robbins,Miwei Hu,Xinrui Cao,Rebecca A. Betensky,Timothy Clark,Sudeshna Das,Bradley T. Hyman +7 more
TL;DR: It is reported that aged tau-overexpressing mice develop changes to blood vessels including abnormal, spiraling morphologies; reduced blood vessel diameters; and increased overall blood vessel density in cortex, which indicates a previously unknown pathway by which pathological tau may accelerate cognitive decline in Alzheimer's disease.
Journal ArticleDOI
Effect of infarcts on dementia in the Baltimore longitudinal study of aging.
Juan C. Troncoso,Alan B. Zonderman,Susan M. Resnick,Barbara J. Crain,Olga Pletnikova,Richard O'Brien +5 more
TL;DR: The magnitude and mechanism of the effect of brain infarcts on the odds of dementia in a prospective study is defined and the likelihood of dementia is estimated.
Journal ArticleDOI
The effects of very early Alzheimer's disease on the characteristics of writing by a renowned author
TL;DR: This paper examined the effects of early stages of Alzheimer's disease on spontaneous written output from an individual with exceptional expertise in this area using automated textual analysis and found that syntax and semantics decline separately or in parallel in patients with dementia.
Journal ArticleDOI
Insights from semantic dementia on the relationship between episodic and semantic memory
TL;DR: It is found that patients with impaired semantic memory showed relatively preserved performance on tests of recognition memory if the stimuli were perceptually identical between learning and test.
Journal ArticleDOI
Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies
Takashi Horiguchi,Kunihiro Uryu,Benoit I. Giasson,Harry Ischiropoulos,Richard Lightfoot,Christine Bellmann,Christiane Richter-Landsberg,Virginia M.-Y. Lee,John Q. Trojanowski +8 more
TL;DR: A monoclonal antibody, n847, which recognizes nitrated tau and alpha-synuclein is generated, implying that nitrative injury is directly linked to the formation of filamentous tau inclusions.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more