Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
Ian D'Souza,Parvoneh Poorkaj,Ming Hong,David Nochlin,Virginia M.-Y. Lee,Thomas D. Bird,Gerard D. Schellenberg +6 more
TL;DR: It is shown that missense, silent, and intronic tau mutations can increase or decrease splicing of tau exon 10 (E10) by acting on 3 different cis-acting regulatory elements.
Journal ArticleDOI
Sleep Quality and Preclinical Alzheimer Disease
Yo-El Ju,Jennifer S. McLeland,Cristina D. Toedebusch,Chengjie Xiong,Anne M. Fagan,Stephen P. Duntley,John C. Morris,David M. Holtzman +7 more
TL;DR: Amyloid deposition in the preclinical stage of AD appears to be associated with worse sleep quality but not with changes in sleep quantity, as measured by total sleep time.
Journal ArticleDOI
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.
TL;DR: A mutation at a novel site within Aβ that may promote its deposition and toxicity is reported in a three‐generation Iowa family with autosomal dominant dementia beginning in the sixth or seventh decade of life.
Journal ArticleDOI
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.
Brian J. Bacskai,Stephen T. Kajdasz,R. H. Christie,Cordelia Carter,Dora Games,Peter Seubert,Dale Schenk,Bradley T. Hyman +7 more
TL;DR: Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy and the role of EMT in this clearance.
Journal ArticleDOI
Physiological release of endogenous tau is stimulated by neuronal activity.
TL;DR: It is found that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons, and that AMPA‐induced release of tau is calcium‐dependent.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more