Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
TL;DR: It is concluded that the neurodegenerative processes associated with normal ageing and with Alzheimer's disease are qualitatively different and that Alzheimer's Disease is not accelerated by ageing but is a distinct pathological process.
Journal ArticleDOI
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
Anne Rovelet-Lecrux,Didier Hannequin,G Raux,Nathalie Le Meur,Annie Laquerrière,Anne Vital,Cécile Dumanchin,Sébastien Feuillette,Alexis Brice,Martine Vercelletto,Frédéric Dubas,Thierry Frebourg,Dominique Campion +12 more
TL;DR: It is reported that duplication of the APP locus on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA) causes ADEOAD with CAA.
Journal ArticleDOI
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
Margaret M. Esiri,Fiona E. Matthews,Carol Brayne,P. G. Ince,F. E. Matthews,John H. Xuereb,J C Broome,J McKenzie,M Rossi,Ian G. McKeith,James Lowe,J H Morris +11 more
TL;DR: Alleged Alzheimer-type and vascular pathology were the major pathological correlates of cognitive decline in this elderly sample, as expected, but most patients had mixed disease, challenging conventional dementia diagnostic criteria in this setting.
Journal ArticleDOI
Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease
Alix de Calignon,Manuela Polydoro,Marc Suárez-Calvet,Marc Suárez-Calvet,Christopher William,David H. Adamowicz,Katherine J. Kopeikina,Katherine J. Kopeikina,Rose Pitstick,Naruhiko Sahara,Karen H. Ashe,George A. Carlson,Tara L. Spires-Jones,Bradley T. Hyman +13 more
TL;DR: A transgenic mouse model in which overexpression of human tau P301L is restricted to EC-II is described, suggesting that a sequence of progressive misfolding of tau proteins, circuit-based transfer to new cell populations, and deafferentation induced degeneration are part of a process of t Tau-induced neurodegeneration.
Journal ArticleDOI
Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.
TL;DR: Investigation of the gastric myenteric and submucosal plexuses in 150 microm cryosections and 8 microm paraffin sections from five autopsy individuals found alpha-synuclein immunoreactive inclusions were found in neurons of the subMucosal Meissner plexus, whose axons could provide the first link in an uninterrupted series of susceptible neurons that extend from the enteric to the central nervous system.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more