Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.
TL;DR: It is found that levels of multiple oxidized bases in AD brain specimens were significantly higher in frontal, parietal, and temporal lobes compared to control subjects and that mitochondrial DNA had approximately 10‐fold higher levels of oxidizer bases than nuclear DNA, consistent withHigher levels of oxidative stress in mitochondria.
Journal ArticleDOI
Functional Network Disruption in the Degenerative Dementias
TL;DR: A better understanding of network disruption in the neurodegenerative dementias might help bridge the gap between molecular changes, pathological changes, and symptoms, allowing earlier detection of neuro degenerative diseases even at the presymptomatic stage, and tracking of disease progression.
Journal ArticleDOI
Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.
Elisabeth H. Thijssen,Elisabeth H. Thijssen,Renaud La Joie,Amy Wolf,Amelia Strom,Ping Wang,Leonardo Iaccarino,Viktoriya Bourakova,Yann Cobigo,Hilary W. Heuer,Salvatore Spina,Lawren VandeVrede,Xiyun Chai,Nicholas K. Proctor,David C. Airey,Sergey Shcherbinin,Cynthia Duggan Evans,John R. Sims,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Anna Karydas,Charlotte E. Teunissen,Joel H. Kramer,Lea T. Grinberg,William W. Seeley,Howie Rosen,Bradley F. Boeve,Bruce L. Miller,Gil D. Rabinovici,Jeffrey L. Dage,Julio C. Rojas,Adam L. Boxer +32 more
TL;DR: Plasma pTau181 concentrations are elevated specifically in patients diagnosed with Alzheimer’s disease compared to those diagnosed with frontotemporal lobar degeneration or elderly controls, supporting its further development as a blood-based biomarker for AD.
Journal ArticleDOI
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
Cristian A. Lasagna-Reeves,Diana L. Castillo-Carranza,Urmi Sengupta,José Sarmiento,José Sarmiento,Juan C. Troncoso,George R. Jackson,Rakez Kayed +7 more
TL;DR: A novel tau oligomer‐specific antibody is engineered and used to elucidate the temporal course and biochemical features of oligomers during NFT development in AD brain and highlight the suitability of tAU oligomers as therapeutic targets in AD and related tauopathies.
Journal ArticleDOI
Stability of the preclinical episodic memory deficit in Alzheimer's disease
TL;DR: The results indicate that Alzheimer's disease is characterized by a long preclinical period during which episodic memory deficits are detectable, and the magnitude of these deficits appears to be quite stable, at least up to 3 years before diagnosis.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more