Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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A novel in vivo atlas of human hippocampal subfields using high-resolution 3 T magnetic resonance imaging.
Julie L. Winterburn,Jens C. Pruessner,Sofia Chavez,Sofia Chavez,Mark M. Schira,Mark M. Schira,Nancy J. Lobaugh,Nancy J. Lobaugh,Aristotle N. Voineskos,Aristotle N. Voineskos,M. Mallar Chakravarty,M. Mallar Chakravarty +11 more
TL;DR: By using these acquisition techniques, the data results in contrast-to-noise ratios that compare well with high-resolution images acquired with long scan times using post-mortem data at higher field strengths, and ultimately be utilized in different analysis pipelines.
Journal ArticleDOI
Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment
Carmen E. Westerberg,Bryce A. Mander,Susan M. Florczak,Sandra Weintraub,M.-Marsel Mesulam,Phyllis C. Zee,Ken A. Paller +6 more
TL;DR: It is suggested that sleep changes in aMCI patients contribute to memory impairments by interfering with sleep-dependent memory consolidation.
Journal ArticleDOI
Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy.
TL;DR: A comprehensive understanding of the properties and applications of exosomes, including their biogenesis, biofunctions, isolation, purification, and drug loading, and typical examples in drug delivery and therapy are provided.
Journal ArticleDOI
Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.
TL;DR: The ultrastructural studies assessing AD-related synaptic loss are reviewed and the possible compensatory changes in the synaptic complex that occur as a result of the loss in brain connectivity are reviewed.
Journal ArticleDOI
Prevalence of dementia disorders in the oldest-old: an autopsy study
TL;DR: This retrospective study using strict morphologic criteria confirmed increased prevalence of AD with age, but mild decline at age 90+, and progressive decline of VD, while AD + vascular pathologies including MIX showed considerable age-related increase, confirming that mixed pathologies account for most dementia cases in very old persons.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more