Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
More filters
Journal ArticleDOI
Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease
Nina Kemppainen,Sargo Aalto,I. A. Wilson,K. Någren,Semi Helin,A. Brück,Vesa Oikonen,Marita Kailajärvi,Mika Scheinin,Matti Viitanen,Riitta Parkkola,Juha O. Rinne +11 more
TL;DR: Voxel-based analysis revealed widespread distribution of increased [11C]PIB uptake in Alzheimer disease (AD), in accordance with the distribution and phases of amyloid pathology in AD, previously documented in postmortem studies.
Journal ArticleDOI
Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin–1 gene
Andrew J Larner,M. Doran +1 more
TL;DR: The clinical phenotypes of reported PSEN1 mutations are reviewed, emphasizing their heterogeneity, and suggesting that other factors, both genetic and epigenetic,must contribute to disease phenotype.
Journal ArticleDOI
Resolution of inflammation is altered in Alzheimer's disease
Xiuzhe Wang,Mingqin Zhu,Erik Hjorth,Veronica Cortés-Toro,Helga Eyjolfsdottir,Caroline Graff,Inger Nennesmo,Jan Palmblad,Maria Eriksdotter,Kumar Sambamurti,Jonathan M. Fitzgerald,Charles N. Serhan,Ann-Charlotte Granholm,Marianne Schultzberg +13 more
TL;DR: Resolution is the final stage of the inflammatory response, when restoration of tissue occurs and may lead to chronic inflammation, which is known as part of the pathology in the brain of individuals with Alzheimer's disease.
Journal ArticleDOI
Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease
Claudio Liguori,Andrea Romigi,Marzia Nuccetelli,S. Zannino,Giuseppe Sancesario,Alessandro Martorana,Maria Albanese,Nicola Biagio Mercuri,Francesca Izzi,Sergio Bernardini,Alessandra Nitti,Giulia Maria Sancesario,Francesco Sica,Maria Grazia Marciani,Fabio Placidi +14 more
TL;DR: The results demonstrate that, in AD, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with cognitive decline.
Journal ArticleDOI
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
David J. Irwin,Todd J. Cohen,Murray Grossman,Steven E. Arnold,Sharon X. Xie,Virginia M.-Y. Lee,John Q. Trojanowski +6 more
TL;DR: In this paper, the abnormal acetylation of tau at lysine residue 280 is a novel, pathological post-translational modification, resulting in decreased solubility and altered microtubule-stabilizing properties.
References
More filters
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
Related Papers (5)
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more