Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Alzheimer's Disease Genetics: From the Bench to the Clinic
TL;DR: Genome-wide association studies and whole-exome and Whole-genome sequencing have revealed more than 20 loci associated with AD risk and provided insights into the molecular pathways that are altered in AD pathogenesis, which have provided insight into novel therapeutic targets.
Journal ArticleDOI
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.
Jessica Freiherr,Manfred Hallschmid,William H. Frey,Yvonne F. Brünner,Colin D. Chapman,Christian Hölscher,Suzanne Craft,Fernanda G. De Felice,Christian Benedict +8 more
TL;DR: Molecular mechanisms potentially underlying the memory-enhancing and neuroprotective effects of intranasal insulin are presented and an overview of neuroimaging studies indicating that disturbances in insulin metabolism and altered brain responses to insulin are linked to decreased cerebral volume and especially to hippocampal atrophy is provided.
Journal ArticleDOI
Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood
Louis De Beaumont,Hugo Théoret,David Mongeon,Julie Messier,Suzanne Leclerc,Sébastien Tremblay,Dave Ellemberg,Maryse Lassonde +7 more
TL;DR: The finding that the P3, the CSP as well as neuropsychological and motor indices were altered more than three decades post-concussion provides evidence for the chronicity of cognitive and motor system changes consecutive to sports concussion.
Journal ArticleDOI
Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
Michael Ewers,Michael Ewers,Cathal Walsh,John Q. Trojanowski,Leslie M. Shaw,Ronald C. Petersen,Clifford R. Jack,Howard Feldman,Arun L.W. Bokde,Gene E. Alexander,Philip Scheltens,Bruno Vellas,Bruno Dubois,Michael W. Weiner,Michael W. Weiner,Harald Hampel +15 more
TL;DR: Short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects.
Journal ArticleDOI
Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia
Jeffrey Kaye,Tim Swihart,Diane B. Howieson,Alison Dame,M. M. Moore,T. Karnos,Richard Camicioli,Melvyn J. Ball,Barry Oken,Gary Sexton +9 more
TL;DR: H hippocampus and parahippocampal atrophy occurs at a similar rate regardless of diagnostic group, and those who develop dementia may have smaller hippocampi to begin with, but become symptomatic because of accelerated loss of temporal lobe volume.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more