Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study
Osama Sabri,Marwan N. Sabbagh,John Seibyl,Henryk Barthel,Hiroyasu Akatsu,Yasuomi Ouchi,Kohei Senda,Shigeo Murayama,Kenji Ishii,Masaki Takao,Thomas G. Beach,Christopher C. Rowe,James B. Leverenz,Bernardino Ghetti,James W. Ironside,Ana M. Catafau,Andrew W. Stephens,Andre Mueller,Norman Koglin,Anja Hoffmann,Katrin Roth,Cornelia Reininger,Walter J. Schulz-Schaeffer +22 more
TL;DR: Evaluation of brain β‐amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease and other dementias.
Journal ArticleDOI
Predictive Markers for AD in a Multi-Modality Framework: An Analysis of MCI Progression in the ADNI Population
TL;DR: Whether the multi-modal disease marker (MMDM) can predict conversion from Mild Cognitive Impairment to AD is examined, and experiments reveal that this measure shows significant group differences between MCI subjects who progressed to AD, and those who remained stable for 3 years.
Journal ArticleDOI
Brain amyloid-β oligomers in ageing and Alzheimer’s disease
Sylvain Lesné,Mathew A. Sherman,Marianne K. O. Grant,Michael A. Kuskowski,Julie A. Schneider,David A. Bennett,Karen H. Ashe +6 more
TL;DR: It is proposed that Aβ*56 may play a pathogenic role very early in the pathogenesis of Alzheimer's disease, as well as three amyloid-β oligomers previously described in mouse models, which are studied in several mouse models and systematically in humans.
Journal ArticleDOI
Computer-assisted imaging to assess brain structure in healthy and diseased brains
John Ashburner,John G. Csernansky,Christos Davatzikos,Nick C. Fox,Giovanni B. Frisoni,Paul M. Thompson +5 more
TL;DR: The strengths and limitations of algorithms of existing computer-assisted tools at the most advanced stage of development are described, together with available and foreseeable evidence of their usefulness at the clinical and research level.
Journal ArticleDOI
Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment.
TL;DR: Using a technique that combined the anatomic precision of magnetic resonance imaging with positron emission tomography, severe reductions of metabolism throughout a network of limbic structures were found in patients with mild AD and those with mild cognitive impairment.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more