Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Josep Saura,J.M. Luque,Cesura Andrea,M. Da Prada,V. Chan-Palay,Gerda Huber,J. Löffler,J. G. Richards +7 more
TL;DR: It is concluded that enzyme radioautography with [3H]lazabemide is a reliable high resolution assay for plaque-associated astroglioses in Alzheimer's disease and might, indirectly, be a potential source of cytotoxic free radicals.
Journal ArticleDOI
Synaptic and neuritic alterations during the progression of Alzheimer's disease
TL;DR: The results suggest that abnormal neuronal expression of APP and cytoskeletal proteins in early stages might be involved in the mechanisms of synaptic pathology in AD.
Journal ArticleDOI
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Dimitrije Krstic,Amrita Madhusudan,Jana Doehner,Prisca Vogel,Tina Notter,Claudine Imhof,Abigail Manalastas,Martina Hilfiker,Sandra Pfister,Cornelia Schwerdel,Carsten Riether,Urs Meyer,Irene Knuesel +12 more
TL;DR: It is found that a systemic immune challenge during late gestation predisposes WT mice to develop AD-like neuropathology during the course of aging, and it is suggested that systemic infections represent a major risk factor for the development of AD.
Journal ArticleDOI
Autobiographical memory and executive function in early dementia of Alzheimer type
TL;DR: The autobiographical memory deficit in DAT reflects, it is argued, both impairment in retrieval processes, linked to executive function, and a loss of memory stores.
Journal ArticleDOI
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy AGGREGATION IS TOXIC TO CELLS BUT CAN BE REVERSED BY INHIBITOR DRUGS
Inna Khlistunova,Jacek Biernat,Yipeng Wang,Marcus Pickhardt,Martin von Bergen,Zuzana Gazova,Eckhard Mandelkow,Eva-Maria Mandelkow +7 more
TL;DR: The cell models open up new insights into the relationship between the structure, expression, phosphorylation, aggregation, and toxicity of tauRD that can be used to test current hypotheses on tauopathy and to develop drugs that prevent the aggregation and degeneration of cells.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more