Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia
TL;DR: In this article, the authors collected all cases from autopsy material (N = 904) that had α-synuclein pathology in the dorsal motor nucleus of vagus, substantia nigra, and/or basal forebrain nuclei.
Journal ArticleDOI
Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders
Rik Ossenkoppele,Rik Ossenkoppele,Gil D. Rabinovici,Ruben Smith,Hanna Cho,Michael Schöll,Michael Schöll,Olof Strandberg,Sebastian Palmqvist,Niklas Mattsson,Shorena Janelidze,Alexander Santillo,Tomas Ohlsson,Jonas Jögi,Richard M. Tsai,Renaud La Joie,Joel H. Kramer,Adam L. Boxer,Maria Luisa Gorno-Tempini,Bruce L. Miller,Jae Y. Choi,Young Hoon Ryu,Chul Hyoung Lyoo,Oskar Hansson +23 more
TL;DR: Among patients with established diagnoses at a memory disorder clinic, [18F]flortaucipir PET was able to discriminate AD from other neurodegenerative diseases, and the accuracy and potential utility of this test in patient care require further research in clinically more representative populations.
Journal ArticleDOI
Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study
Claudio Babiloni,Giuliano Binetti,Emanuele Cassetta,Gloria Dal Forno,Claudio Del Percio,Florinda Ferreri,Raffaele Ferri,Giovanni B. Frisoni,Koichi Hirata,Bartolo Lanuzza,Carlo Miniussi,Davide V. Moretti,Flavio Nobili,Guido Rodriguez,Gian Luca Romani,Serenella Salinari,Paolo Maria Rossini +16 more
TL;DR: Functional data on large populations support the 'transitional hypothesis' of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD.
Journal ArticleDOI
Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains
TL;DR: It is found that expression of some GWAS genes, namely ABCA7, BIN1, CD33, CLU, CR1 and the MS4A family, are altered in AD brains, and expression levels were associated with clinical dementia rating (CDR), with higher expression being associated with more advanced cognitive decline.
Journal ArticleDOI
Entorhinal-hippocampal connections: a speculative view of their function
TL;DR: Some of the properties of synaptic transmission in the EC are summarized and how frequency-dependent changes in transmission may be involved in the pre- and post-processing of hippocampal information by the EC is speculated on.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more