Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.Citations
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Feature article: are neurons lost from the primate cerebral cortex during normal aging?
TL;DR: It is concluded that on the basis of the existing data there is no strong evidence to support the concept that significant numbers of neurons are lost from the cerebral cortex during normal aging, and it appears that cortical neurons are largely preserved.
Journal ArticleDOI
Selective Preservation and Degeneration Within the Prefrontal Cortex in Aging and Alzheimer Disease
TL;DR: The orbital PFC is selectively preserved in OHE subjects and degeneration within the PFC with AD is most prominent in the inferior PFC region, suggesting degeneration has a regionally distinct pattern in healthy aging and AD.
Journal ArticleDOI
Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease
Angela L. Guillozet-Bongaarts,Francisco García-Sierra,Matthew R. Reynolds,Peleg M. Horowitz,Yifan Fu,Tianyi Wang,Michael E. Cahill,Eileen H. Bigio,Robert W. Berry,Lester I. Binder +9 more
TL;DR: Creation of the Tau-C3 epitope appears to occur relatively early in the disease state, contemporaneous with the initial Alz50 folding event that heralds the appearance of filamentous tau in NFTs, neuropil threads, and the dystrophic neurites surrounding amyloid plaques.
Journal ArticleDOI
Blood–brain barrier P-glycoprotein function in Alzheimer's disease
Daniëlle M. E. van Assema,Mark Lubberink,Mark Lubberink,Martin Bauer,Wiesje M. van der Flier,Robert C. Schuit,Albert D. Windhorst,Emile F.I. Comans,Nikie J. Hoetjes,Nelleke Tolboom,Oliver Langer,Markus Müller,Philip Scheltens,Adriaan A. Lammertsma,Bart N.M. van Berckel +14 more
TL;DR: Assessment of blood-brain barrier P-glycoprotein function in patients with Alzheimer's disease compared with age-matched healthy controls shows altered kinetics of (R)-[(11)C]verapamil in Alzheimer’s disease, similar to alterations seen in studies where P- glycoprotein is blocked by a pharmacological agent.
Journal ArticleDOI
The cause of neuronal degeneration in Alzheimer's disease.
James C. Vickers,Tracey C. Dickson,Paul A. Adlard,Helen L. Saunders,Carolyn E. King,Graeme H. McCormack +5 more
TL;DR: Therapeutically, inhibition of the neuronal reaction to physical trauma may be a useful neuroprotective strategy in the earliest stages of Alzheimer's disease.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Diagnosis of Alzheimer's Disease
TL;DR: The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD.
Journal ArticleDOI
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
TL;DR: Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex that isolates the hippocampus from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
Journal ArticleDOI
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
TL;DR: Data on the severity of the pathological involvement in different areas of the neocortex and the laminar distribution and the clustering of the tangles support the suggestion that the pathological changes in Alzheimer disease affect regions that are interconnected by well-defined groups of connections and that the disease process may extend along the connecting fibers.
Journal ArticleDOI
Plaques, tangles and dementia. A quantitative study.
G.K. Wilcock,Margaret M. Esiri +1 more
TL;DR: The temporal lobe cortex and hippocampus were the areas most severely affected by the increased neurofibrillary tangle formation in senile dementia due to Alzheimer's disease.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more