Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Journal ArticleDOI
Gut Microbiota, Obesity and Metabolic Dysfunction
Anna Meiliana,Andi Wijaya +1 more
TL;DR: The interaction of the intestinal microbial world with its host, and its mutual regulation, will become one of the important topics of biomedical research and will provide further insights at the interface of microbiota, metabolism, metabolic syndrome, and obesity.
Journal ArticleDOI
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
TL;DR: In this article , the critical stress response pathways that are activated in β cells in the context of the animal models were reviewed in a study conducted in the field of diabetes, and their individual contributions to glucose homeostasis and β-cell health were elucidated through the development and interrogation of animal models.
Book ChapterDOI
Role of Epigenetics in the Complications Associated with Diabetes and Related Metabolic Disorders
Dissertation
The cardiometabolic phenotype of UK South Asian men
TL;DR: This thesis aims to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian, compared to white European men, living in the UK, was due to lower cardiorespiratory fitness and physical activity and whether South Asians have increased liver fat compared to Europeans.
Journal Article
Relationship between Type 2 Diabetes and Inflammation Diseases: Cohort Study in Chinese Adults.
TL;DR: There was a decreased incidence of inflammatory diseases in the diabetic patients compared with non-diabetic subjects, and T2D might reduce the risk of these diseases.
References
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