Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows
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Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance
Wendy Huang,Christopher K. Glass +1 more
TL;DR: Recent studies that advance understanding of signaling pathways involved in initiation of inflammatory responses at the level of transcription and counterregulation of these pathways by selected members of the nuclear receptor superfamily are reviewed.
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Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure
Sanja Soskic,Branislava Dobutovic,Emina Sudar,Milan Obradovic,Dragana Nikolic,Jelena D Djordjevic,Djordje Radak,Dimitri P. Mikhailidis,Esma R. Isenovic +8 more
TL;DR: This review considers the recent animal studies which focus on the understanding of regulation of iNOS activity/expression and the role of i NOS agonists as potential therapeutic agents in treatment of IR, T2DM and HF.
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Dietary and metabolic control of stem cell function in physiology and cancer.
TL;DR: The emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth are explored.
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Role of Innate Immune Response in Non-Alcoholic Fatty Liver Disease: Metabolic Complications and Therapeutic Tools
TL;DR: The relevant role of innate immune cell activation in relation to NAFLD, the metabolic complications associated to this pathology, and the possible pharmacological tools are discussed.
References
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