Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
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Effects of selenium supplementation on serum C reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials
Omid Asbaghi,Somayeh Saboori,Azita Hekmatdoost,Azita Hekmatdoost,Foad Abdollahpour,Esmaeil Yousefi Rad,Shadab Salehpour +6 more
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Immune Neuroendocrine Interactions during a Fungal Infection in Immunocompetent or Immunosuppressed Hosts
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TL;DR: It is found that stress mediators contribute to the spread of the fungus and downregulate critical functions of phagocytic cells at the infection site and perturb the complex immune and metabolic program that operates early during fungal spread and promotes severe tissue damage.
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Obesity and breast cancer
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The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments
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High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha
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TL;DR: An unexpected phenotype is demonstrated in HFD-fed atERαKO involving severe uterine bacterial infections likely resulting from a previously unknown negative interference between dietary FAs and ERα-signaling during anti-microbial defence.
References
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