Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children
TL;DR: The present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children.
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Feast and famine: Adipose tissue adaptations for healthy aging
TL;DR: This perspective view argued some important molecular and metabolic aspects related to adipocyte response to nutrient stress and delineated hypothetical routes by which molecularly and metabolically readapted adipose tissue promotes healthy aging.
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Symposium review: Mechanisms linking metabolic stress with innate immunity in the endometrium.
TL;DR: It is suggested that stressing cellular metabolism increases the risk of uterine disease by impairing endometrial defenses and impairs the inflammatory response to pathogens.
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Mannose-Binding Lectin is required for the effective clearance of apoptotic cells by adipose tissue macrophages during obesity
Rinke Stienstra,Rinke Stienstra,Wieneke Dijk,Lianne van Beek,H.J. Jansen,Mattijs M. Heemskerk,Riekelt H. Houtkooper,Simone Denis,Vanessa van Harmelen,Ko Willems van Dijk,Cees J. Tack,Sander Kersten +11 more
TL;DR: A novel role is proposed for MBL in the recognition and clearance of apoptotic adipocytes during obesity by enhancing phagocytic capacity of the stromal vascular fraction isolated from adipose tissue and modulated uptake of apoptosis by macrophages.
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RNA N6-methyladenosine: a promising molecular target in metabolic diseases.
TL;DR: The biological and clinical significance of RNA N6-methyladenosine modification in metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, hypertension, cardiovascular diseases, osteoporosis and immune-related metabolic diseases are summarized.
References
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Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
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David Ron,Peter Walter +1 more
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