Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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The adaptive immune role of metallothioneins in the pathogenesis of diabetic cardiomyopathy: good or bad
TL;DR: Aberrant immune regulation in diabetic heart disease is discussed with respect to endothelial insulin resistance and the effects of hyperglycemia and hyperlipidemia on tissues and the different effects of intracellular and extracellular MTs on adaptive immunity are shown.
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Essential role of methyl donors in animal productivity
TL;DR: Evidence showing that methyl donors activate adenosine monophosphate-activated protein kinase, an anti-inflammatory master switch, indicates that dietary methyl-donor supplementation could be used to prevent or ameliorate chronic inflammation and its sequelae in livestock.
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Relationship of tumour-associated macrophages with poor prognosis in Wilms' tumour.
TL;DR: There is a high density of TAMs in WT, and M2-type macrophage density increases with tumour progression and implies a poor prognosis, which can be utilized as a new indicator in pathological examination.
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Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790
Simon Schneider,Petra Hoppmann,Werner Koch,Stephan Kemmner,Christoph Schmaderer,Lutz Renders,Adnan Kastrati,Karl-Ludwig Laugwitz,Uwe Heemann,Marcus Baumann +9 more
TL;DR: Systolic blood pressure increase with obesity was blunted in cases with TLR4 SNP rs4986790, which was an independent predictor of SBP in obesity.
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Lean/normal‐weight metabolic dysfunction‐associated fatty liver disease is a risk factor for reflux esophagitis
Shuhei Fukunaga,Dan Nakano,Tsubasa Tsutsumi,Takumi Kawaguchi,Mohammed Eslam,Shinobu Yoshinaga,Hirohiko Abe,Ryuichi Nouno,Se Heon Joh,Keiichi Mitsuyama,Jacob George,Takuji Torimura +11 more
TL;DR: This work investigated the impact of MAFLD and its subtypes on the incidence of reflux esophagitis and found that fatty liver has been redefined as metabolic dysfunction‐associated fatty liver disease.
References
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