Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice.
Zhang Yi,Mo Fangfang,Zhang Dongwei,Gao Sihua,Zhao Dandan,Yu Na,Mu Qianqian,Zuo Jiacheng,Ma Yue +8 more
TL;DR: Treatment with JTXK granule attenuates glucose disorders, improves insulin sensitivity, and reduces serum FFA in T2DM KK-Ay mice, which may be attributed to regulation of the signaling ER stress pathway via decreasing eIF2α phosphorylation and suppressing eif2α-ATF4-CHOP activation.
Journal ArticleDOI
Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity
TL;DR: In this article , the authors investigated the effect of time-restricted feeding on myeloid cell proliferation in overweight and obese mice and found that it may help maintain immune cell homeostasis in bone marrow and circulation during obesity, which may contribute to health benefits associated with TRF.
Journal ArticleDOI
Impact of Gut Microbiota on the Risk of Cardiometabolic Diseases Development
L. E. Vasilyeva,O. M. Drapkina +1 more
TL;DR: In this paper, a review of literature about assessment of relationship between composition and functions of intestinal microbiota in the diagnostics, prevention and treatment of obesity and cardiovascular diseases is presented. And it is proved that Gut microbiota affects extraction, accumulation and consumption of energy derived from food, lipid metabolism and immune response.
Book ChapterDOI
Control of Body Weight and the Modern Metabolic Diseases
TL;DR: The increase in the body weight in the world population has become one of the most important public health problems, as it is a major risk factor for several pathologies such as cardiovascular diseases and diabetes.
Journal ArticleDOI
Physiological mechanisms of TLR4 in glucolipid metabolism regulation: Potential use in metabolic syndrome prevention.
TL;DR: The role of TLR4 in the regulation of glucolipid metabolism as well as its physiological mechanisms was discussed in this article , which enriched mechanistic research of diabetes, atherosclerosis, and other nutrition-related disorders.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Inflammation and metabolic disorders
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Journal ArticleDOI
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TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron,Peter Walter +1 more
TL;DR: Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids.