Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais.
Jirayu Lainampetch,Pornpimol Panprathip,Chanchira Phosat,Noppanath Chumpathat,Pattaneeya Prangthip,Ngamphol Soonthornworasiri,Somchai Puduang,Naruemon Wechjakwen,Karunee Kwanbunjan +8 more
TL;DR: It is suggested that IL-6 outstandingly plays a contributing role in T2 DM progression and elevated TNF-α levels over time could be a potential predictor of T2DM.
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Network analysis: a new approach to study endocrine disorders
Adam Stevens,C De Leonibus,Dan Hanson,Andrew W. Dowsey,Andrew Whatmore,Stefan Meyer,Rachelle Donn,P Chatelain,Indraneel Banerjee,Karen E. Cosgrove,Peter E. Clayton,Mark J. Dunne +11 more
TL;DR: An overview of network methods used to support systems biology research, an insight into current applications of network analysis applied to endocrinology and the development of personalised treatment strategies which will integrate pharmacogenomics with systems biology of the individual are provided.
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Rice bran prevents high-fat diet-induced inflammation and macrophage content in adipose tissue.
Maria Luisa Justo,Carmen Claro,Maximilian Zeyda,Thomas M. Stulnig,Maria Dolores Herrera,Rosalía Rodríguez-Rodríguez,Rosalía Rodríguez-Rodríguez +6 more
TL;DR: RBEE-supplemented diet attenuated insulin resistance, dyslipidemia and morphological and functional alterations of adipose tissue in DIO mice, and may be considered an alternative nutritional complement over metabolic syndrome and its complications.
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Metabolic stress drives sympathetic neuropathy within the liver.
TL;DR: In this paper, the authors examined neural distributions in the mouse, nonhuman primate, and human livers with advanced 3D imaging and found that neural innervations within the liver are predominantly sympathetic, but not parasympathetic, inputs.
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Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and LS14 human adipose cell line ☆
Mariana Cifuentes,Cecilia Fuentes,Pamela Mattar,Nicolás Tobar,Eric R. Hugo,Nira Ben-Jonathan,Cecilia V. Rojas,Jorge Martínez +7 more
TL;DR: Observations that proinflammatory factors increase CaSR levels in adipocytes, and the reported ability of CaSR to elevate cytokine levels, open new aspects in the study of obesity inflammatory state pathophysiology, providing a potential novel therapeutic prevention and treatment target.
References
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