Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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Somatostatin Derivate (smsDX) Attenuates the TAM-Stimulated Proliferation, Migration and Invasion of Prostate Cancer via NF-κB Regulation
Zhaoxin Guo,Zhaoquan Xing,Xiangyu Cheng,Zhiqing Fang,Chao Jiang,Jing Su,Zunlin Zhou,Zhonghua Xu,Anders R. Holmberg,Sten Nilsson,Zhaoxu Liu +10 more
TL;DR: Investigation into the underlying mechanism revealed that NF-κB played an important role in macrophage infiltration and SmsDX inhibited the paracrine loop between TAM and PCa cells and may represent a potential therapeutic agent for PCa.
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Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism.
Matthieu Ruiz,Lise Coderre,Bruce G. Allen,Bruce G. Allen,Christine Des Rosiers,Christine Des Rosiers +5 more
TL;DR: A growing body of evidence now supports a key role of MK2 signaling in the pathogenesis of CVD, particularly ischemia/reperfusion injury, hypertrophy, and hypertension and that its inhibition or inactivation is associated with improved heart and vascular functions.
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Molecular classification of fatty liver by high-throughput profiling of protein post-translational modifications.
TL;DR: An alternative approach to classifying fatty liver by profiling protein post‐translational modifications (PTMs) with high‐throughput capillary isoelectric focusing (cIEF) immunoassays with the potential to provide molecular classification of fatty liver.
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Influence of Yeast Products on Modulating Metabolism and Immunity in Cattle and Swine
TL;DR: This paper explored the influence of yeast products on metabolism in cattle and swine, and how changes in metabolism and energy availability may contribute to improvements in immune function in supplemented animals, as the energy demands of an activated immune system are extremely high.
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Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
Xin Guo,Chang Shu,Honggui Li,Ya Pei,Shih Lung Woo,Juan Zheng,Mengyang Liu,Hang Xu,Rachel Botchlett,Ting Guo,Yuli Cai,Xinsheng Gao,Jing Zhou,Lu Chen,Qifu Li,Xiaoqiu Xiao,Linglin Xie,Ke Zhang,Jun-Yuan Ji,Yuqing Huo,Yuqing Huo,Fanyin Meng,Gianfranco Alpini,Pingwei Li,Chaodong Wu +24 more
TL;DR: In obese mice, treatment with cGAMP significantly decreases diet-induced proinflammatory responses in liver and adipose tissues and ameliorates metabolic dysregulation, indicating potential applications of cGamp in treating obesity-associated inflammatory and metabolic diseases.
References
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