Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
Citations
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MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes
TL;DR: The main mechanisms involved in the activation of obesity-associated metabolic inflammation are presented and potential therapeutic opportunities that can be developed to treat obesity- associated metabolic diseases are discussed.
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Lipopolysaccharide (LPS)-stimulated iNOS Induction Is Increased by Glucosamine under Normal Glucose Conditions but Is Inhibited by Glucosamine under High Glucose Conditions in Macrophage Cells.
Ji Sun Hwang,Mi Youn Kwon,Kyung Hong Kim,Yunkyoung Lee,In Kyoon Lyoo,Ji-Eun Kim,Eok Soo Oh,Inn-Oc Han +7 more
TL;DR: The results suggest that GlcN regulates inflammation by sensing energy states of normal and fuel excess by suppressing LPS-induced up-regulation of COX-2, IL-6, and TNF-α mRNAs under 25 mm glucose conditions and blocking transcription with actinomycin D increases stability of L PS-induced iNOS mRNA under normal glucose conditions.
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Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?
TL;DR: This review aims at providing a comprehensive update of the relationship between the adipose tissue in obesity and autoimmune disorders, highlighting the underlying mechanisms with a particular emphasis on adipokines and pro-inflammatory cytokines, the impaired B cell activity, and the production of natural and pathogenic autoantibody repertoire in the context of obesity.
OtherDOI
Circadian Rhythms in Adipose Tissue Physiology
Jana-Thabea Kiehn,Anthony H. Tsang,Isabel Heyde,Brinja Leinweber,Isa Kolbe,Alexei Leliavski,Henrik Oster +6 more
TL;DR: Current knowledge about the crosstalk between circadian clocks and energy metabolism with a focus on adipose physiology is summarized.
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Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research?
TL;DR: The purpose of this review is to discuss the different mechanisms that drive ATM-mediated inflammation in obesity and present current evidence of how exercise training, specifically endurance exerciseTraining, modulates the polarization of ATMs from an M1 to an M2 anti-inflammatory phenotype.
References
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