Nutrient sensing and inflammation in metabolic diseases.
TLDR
This Review provides an overview of several important networks that sense and manage nutrients and discusses how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.Abstract:
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.read more
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The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach.
Dulce Calçada,Dario Vianello,Enrico Giampieri,Claudia Sala,Gastone Castellani,Albert A. de Graaf,Bas Kremer,Ben van Ommen,Edith J. M. Feskens,Aurelia Santoro,Claudio Franceschi,Jildau Bouwman +11 more
TL;DR: M Mathematical modeling of inflammation and metabolic regulation, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems.
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Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes
Tsuyoshi Goto,Supaporn Naknukool,Rieko Yoshitake,Yuki Hanafusa,Soshi Tokiwa,Yongjia Li,Tomoya Sakamoto,Takahiro Nitta,Min-Ji Kim,Nobuyuki Takahashi,Rina Yu,Hiromi Daiyasu,Shigeto Seno,Hideo Matsuda,Teruo Kawada +14 more
TL;DR: The findings suggest that IL-1β upregulated in obese adipose tissues suppresses β-adrenoreceptor-stimulated induction of UCP1 expression through ERK activation in adipocytes.
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Obesity and its associated disease: a role for microbiota?
Ali Bonakdar Tehrani,Behtash Ghazi Nezami,Behtash Ghazi Nezami,Andrew T. Gewirtz,Shanthi Srinivasan +4 more
TL;DR: The gut microbiota are implicated in the pathogenesis of the obesity and its related metabolic diseases and host innate and adaptive immune responses define an individual’s gut microbiota.
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The pathophysiology of abdominal adipose tissue depots in health and disease.
TL;DR: The present review will examine the phenotypic and pathophysiological differences between the different AT depots, with a particular focus on the abdominal depots and their link to metabolic complications.
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Potential for therapeutic manipulation of the UPR in disease
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TL;DR: This work focuses on the molecular signaling pathways of the UPR and suggests possible ways to target this response for therapeutic purposes.
References
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